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CSN3 — IFI27

Text-mined interactions from Literome

Sugiyama et al., J Biol Chem 2001 : Overexpression of Grb2 accelerates Jab1/CSN5 mediated degradation of p27 , while Grb3-3 expression suppresses it
Tomoda et al., J Biol Chem 2002 : Nuclear-cytoplasmic translocation plays an important role because leptomycin B ( LMB ), a chemical inhibitor of CRM1 dependent nuclear export, prevents p27 degradation mediated by Jab1/CSN5 ... A Jab1/CSN5 truncation mutant lacking NES reversed p27 down-regulation induced by the full-length Jab1/CSN5 , indicating that this mutant functions as a dominant negative ( DN-Jab1 )
Pan et al., Cancer Res 2012 (Nasopharyngeal Neoplasms) : Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma ... Aberrant expression of Jab1/CSN5 , a negative regulator of the cell-cycle inhibitor p27 , is correlated with reduced p27 expression and associated with advanced tumor stage and poor prognosis in several human cancers