Gene interactions and pathways from curated databases and text-mining

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AR — EGF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: EGF → AR (increases, EGF Activity) Mabjeesh et al., Clin Cancer Res 2003*
    Evidence: This induction was not seen either when LNCaP cells were treated with flutamide or conditioned medium were pretreated with antibody to the epidermal growth factor (EGF)
  • OpenBEL Selventa BEL large corpus: Complex of AR-NCOA2 → EGF (increases)
    Evidence: Site-specific mutagenesis and selective MAPK inhibitors linked the EGF-induced increase in AR transactivation to phosphorylation of TIF2/GRIP1. EGF signaling increased the coimmunoprecipitation of TIF2 and AR. AR transactivation and its stimulation by EGF were reduced by small interfering RNA inhibition of TIF2/GRIP1 expression. The data indicate that EGF signaling through MAPK increases TIF2/GRIP1 coactivation of AR transactivation in recurrent prostate cancer.

Text-mined interactions from Literome

Mizokami et al., Endocrinol Jpn 1992 (Prostatic Neoplasms) : Regulation of androgen receptor by androgen and epidermal growth factor in a human prostatic cancer cell line, LNCaP
Migliaccio et al., Cancer Res 2005 (Breast Neoplasms...) : Interestingly, EGF triggers rapid association of Src with androgen receptor (AR) and estradiol receptor alpha (ERalpha) in MCF-7 cells or ERbeta in LNCaP cells
Jia et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 (Prostatic Hyperplasia) : To investigate the effects of epidermal growth factor (EGF) on estrogen receptor ( ER ) and androgen receptor (AR) in mouse prostate cells and explore the putative role of EGF in prostatic hyperplasia
Aaronson et al., Mol Cell Endocrinol 2007 (Prostatic Neoplasms) : Increasing the protein levels of the signal transducer and activator of transcription 3 ( Stat3 ) led to Stat3-androgen receptor (AR) complex formation in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) stimulation ... Increasing the protein levels of Stat3 increased the EGF induced transcriptional activation of the androgen receptor