Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
EGF
→
AR
(increases, EGF Activity)
Mabjeesh et al., Clin Cancer Res 2003* Evidence: This induction was not seen either when LNCaP cells were treated with flutamide or conditioned medium were pretreated with antibody to the epidermal growth factor (EGF)
OpenBEL Selventa BEL large corpus:
Complex of AR-NCOA2
→
EGF
(increases)
Evidence: Site-specific mutagenesis and selective MAPK inhibitors linked the EGF-induced increase in AR transactivation to phosphorylation of TIF2/GRIP1. EGF signaling increased the coimmunoprecipitation of TIF2 and AR. AR transactivation and its stimulation by EGF were reduced by small interfering RNA inhibition of TIF2/GRIP1 expression. The data indicate that EGF signaling through MAPK increases TIF2/GRIP1 coactivation of AR transactivation in recurrent prostate cancer.