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ELAVL1 — MYC
Text-mined interactions from Literome
Kim et al., Genes Dev 2009
:
Here, we show that the RBP
HuR reduced
c-Myc expression by associating with the c-Myc 3 ' untranslated region ( UTR ) next to a miRNA let-7 binding site ... Unexpectedly,
HuR and let-7
repressed c-Myc through an interdependent mechanism, as let-7 required HuR to reduce c-Myc expression and HuR required let-7 to inhibit c-Myc expression ... Our findings suggest a regulatory paradigm wherein
HuR inhibits
c-Myc expression by recruiting let-7 loaded RISC ( RNA miRNA induced silencing complex ) to the c-Myc 3'UTR
Talwar et al., J Biol Chem 2011
(Carcinoma, Squamous Cell...) :
Caspase mediated cleavage of RNA binding protein
HuR regulates
c-Myc protein expression after hypoxic stress
Perrone et al., J Surg Res 2012
:
Bile salts increase epithelial cell proliferation through
HuR induced
c-Myc expression