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SAA3P — TNF

Text-mined interactions from Literome

Son et al., Endocrinology 2004 : Overexpression of the inhibitor of NF-kappaB ( called IkappaB ) blocked SAA3 promoter activity induced by TNF and by p65 in OV3121-1 cells ... TNF also increased phospho-IkB and SAA3 in whole-cell homogenates as determined by Western blots ... Thus, TNF likely increased SAA3 promoter activity and protein by activating NF-kappaB signaling via TNFR1 in mouse granulosa cells
Son et al., Endocrinology 2010 : Because ovulation is an inflammatory reaction and TNF specifically induces serum amyloid A3 (SAA3) in mouse granulosa cells, the effect of cAMP on TNF induced SAA3 promoter activity, mRNA and protein was investigated ... TNF increased SAA3 promoter activity, mRNA, and protein, which were further increased by cAMP ... Thus, there appeared to be different mechanisms by which TNF and cAMP regulated SAA3 expression ... Among four CCAAT enhancing binding protein (C/EBP) sites in the SAA3 promoter, the C/EBP site nearest the NF-kappaB-like site was required for TNF induced SAA3