Gene interactions and pathways from curated databases and text-mining

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TNF — TYMP

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: TYMP → TNF (increases) Zhu et al., Oncogene 2002*
    Evidence: Treatment of TNF-alpha induced TP activity begininng at 12 h which was maximal at 48 h in WiDr cells. The induction of TP enzymatic activity was accompanied by the increase in mRNA levels.

Text-mined interactions from Literome

Zhu et al., Oncogene 2002 (Adenocarcinoma...) : The Sp1 transcription factor contributes to the tumor necrosis factor induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells
Zhang et al., Endocrinology 1997 (Adenocarcinoma...) : Thus, in NEE cells, PD-ECGF/TP expression was strongly induced by the combination tumor necrosis factor-a and interferon-gamma