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IL13 — JAK1

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Doucet et al., Eur J Immunol 2002 (Inflammation) : Treatment with JAK3 inhibitors blocks IL-13 induced phosphorylation of JAK2, TYK2 and STAT3, but not of JAK1 and STAT6
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Russell et al., Islets 2013 : Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic ß-cells
Keegan et al., Proc Natl Acad Sci U S A 1995 : In this report we demonstrate that both IL-4 and IL-13 induced the tyrosine phosphorylation of 4PS and JAK1
Welham et al., J Biol Chem 1995 (Leukemia, Erythroblastic, Acute...) : Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1
Murata et al., J Immunol 1996 (Colonic Neoplasms) : IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines : similarities between IL-4 and IL-13 signaling
Murata et al., Blood 1998 : Taken together, our results show that IL-13Ralpha ' is a novel functional component of the IL-4R system and that JAK1 and JAK2 mediate IL-4 induced optimal activation of STAT6 in nonhematopoietic cells