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FGFR1 — PI3
Text-mined interactions from Literome
Hart et al., Oncogene 2000
(Cell Transformation, Neoplastic) :
Finally, we demonstrate that
FGFR1 , FGFR3, and FGFR4 derivatives can
stimulate PI-3 kinase activity ... Finally, we demonstrate that FGFR1,
FGFR3 , and FGFR4 derivatives can
stimulate PI-3 kinase activity
Shi et al., Zhonghua Yi Xue Za Zhi 2004
(Breast Neoplasms) :
T47D cells were inoculated into a 24-well plate, co-transfected with luciferase vector OB-HRE containing HIF-1 functional sequence ( HRE ) and pRL-SV40 ( as inner marker ), pretreated with SU5402, inhibitor of
FGFR1 , SB203580,
inhibitors of
PI-3K , PD98059, inhibitors of MEK1, or LY294002, inhibitors of p38, treated with basic fibroblast growth factor (bFGF), and then lysed
Mavila et al., PloS one 2012
(Liver Neoplasms) :
FGF Receptor ( R ) activation
resulted in the downstream activation of MAPK,
PI3K-AKT , and ß-catenin pathways, as well as cellular proliferation
Landgren et al., Oncogene 1998
:
Although the
FGFR-1 only very inefficiently
mediates activation of phosphatidylinositol 3 ' kinase (
PI 3-kinase ), the PI 3-kinase inhibitor wortmannin suppressed wild-type FGFR-1 mediated migration