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FASLG — FOXO3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database FoxO family signaling:
FOXO3A (FOXO3)
→
FASLG (FASLG)
(transcription, activates)
Brunet et al., Cell 1999, Brunet et al., Science 2004
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database FoxO family signaling:
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
→
FASLG (FASLG)
(transcription, inhibits)
Brunet et al., Cell 1999, Brunet et al., Science 2004
Evidence: mutant phenotype, reporter gene
-
WikiPathways DNA Damage Response (only ATM dependent):
FOXO3
→
Complex of FASLG-BCL2L11-BCL6-BBC3
(activation)
Text-mined interactions from Literome
Suhara et al., Mol Cell Biol 2002
:
Similarly,
induction of
FasL by the Akt regulated forkhead transcription factor
FKHRL1 was dependent upon caspase and c-Jun activation ... Taken together, these results indicate that the sequential activation of caspase 3 and c-Jun participates in the induction of
FasL under conditions of suppressed Akt signaling or
FKHRL1 activation and that FasL participates in a positive-feedback loop to promote cell death under conditions of cellular stress
Behzad et al., Cytokine 2007
:
Cytokine mediated
FOXO3a phosphorylation
suppresses FasL expression in hemopoietic cell lines : investigations of the role of Fas in apoptosis due to cytokine starvation