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IRAK3 — TLR4

Text-mined interactions from Literome

Kobayashi et al., Cell 2002 (Salmonella Infections) : Thus, IRAK-M regulates TLR signaling and innate immune homeostasis ... Thus, IRAK-M regulates TLR signaling and innate immune homeostasis
Hazeki et al., Eur J Immunol 2003 : PP2, an inhibitor of Src family tyrosine kinases, prevented the TLR induced phosphorylation of paxillin and Pyk2 without affecting TLR induced IRAK activation
Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK , ERK 1/2, p38, and JNK/SAPK
Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK , TRAF6, and Toll interacting protein (Tollip), but not TIRAP, were involved in the TLR mediated response to P. aeruginosa in HAECs
Pathak et al., J Biol Chem 2005 : Man-LAM exerts these effects by inducing the expression of Irak-M , a negative regulator of TLR signaling
Seki et al., J Immunol 2010 (Acute Lung Injury...) : We investigated the role of IL-1 receptor associated kinase-M ( IRAK-M ), an inhibitor of MyD88 dependent TLR signaling, in modulating the innate inflammatory response during influenza pneumonia using a murine model
Turnis et al., J Immunol 2010 : We found that IRAK-M is induced in DCs by TLR ligation and that its absence from these cells leads to increased activation of the p38-MAPK and NF-?B pathways, which, in turn, improves DC migration to lymph nodes, increases their longevity, and augments their secretion of Th1 skewing cytokines and chemokines
Biswas et al., Eur J Immunol 2011 (Colitis...) : Interestingly, the expression of IRAK-M , a negative regulator of TLR signaling, is dependent on intestinal commensal flora, as IRAK-M expression was reduced in mice re-derived into a germ-free environment, and introduction of commensal bacteria into germ-free mice induced IRAK-M expression
Wu et al., J Allergy Clin Immunol 2012 (Asthma) : IL-1 receptor associated kinase M ( IRAK-M ) negatively regulates TLR signaling
Cole et al., Immunol Lett 2012 : This study tested if murine bone marrow derived dendritic cells ( BM-DCs ) respond to endotoxin- and bacterial sonicate induced tolerance by decreased inflammatory and increased anti-inflammatory response, and the role of IRAK-M , an intracellular negative regulator of TLR signaling, in this tolerance
Villena et al., Clinical and vaccine immunology : CVI 2012 : Our results also indicated that TLR2 has an important role in the anti-inflammatory activity of L. jensenii TL2937, since anti-TLR2 antibodies blocked the upregulation of SIGIRR and IRAK-M in CD172a ( + ) APCs and the production of IL-10 in response to TLR4 activation
Sandig et al., Eur J Immunol 2013 : We show that while IRAK2 is redundant for TLR4 signaling, IRAK1 is essential for TLR4 signaling in mast cells
Shiu et al., PloS one 2013 (Helicobacter Infections) : IRAK-M , a negative regulator of TLR signaling, was upregulated and we selectedit for investigation of its role in modulating the DC and T cell responses
Sung et al., Biochem Biophys Res Commun 2013 : Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages ... Pro B2 markedly elevated the expression of the interleukin (IL)-1 receptor associated kinase ( IRAK)-M protein, a negative regulator of TLR signaling