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EGFR — PTPRJ
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Berset et al., Genes Dev 2005
:
During vulval development,
DEP-1 inhibits
EGFR signaling in the secondary cell lineage in parallel with the NOTCH mediated lateral inhibition, while EGFR signaling simultaneously down-regulates DEP-1 and NOTCH expression in the primary cell lineage
Tarcic et al., Curr Biol 2009
:
DEP-1 is a tumor suppressor that dephosphorylates and thereby
stabilizes EGFR by hampering its ability to associate with the CBL-GRB2 ubiquitin ligase complex