Gene interactions and pathways from curated databases and text-mining

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ADAM10 — ADAM17

Text-mined interactions from Literome

Abel et al., J Immunol 2004 : The constitutive shedding of CXCL16 from the endothelial cell surface is blocked by inhibitors of ADAM10 and is independent of additional inhibition of ADAM17
Peng et al., Neuroscience 2007 (Alzheimer Disease...) : Hup A enhanced the level of ADAM10 , and the inhibitor of tumor necrosis factor-alpha converting enzyme ( TACE ) /ADAM17 inhibited the Hup A-induced rise in alphaAPPs levels, further suggesting Hup A directed APP metabolism toward the non-amyloidogenic alpha-secretase pathway
Linford et al., Dev Cell 2012 : In FAM116A- and Rab14 depleted cells, ADAM10 accumulates in a transferrin positive endocytic compartment, and the cell-surface level of ADAM10 is correspondingly reduced