Gene interactions and pathways from curated databases and text-mining

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PRX — TXN

Text-mined interactions from Literome

Myers et al., Toxicology 2009 : Normally, thioredoxin reductase (TrxR) maintains the cytosolic ( Trx1 ) and mitochondrial ( Trx2 ) thioredoxins in the reduced state, and the thioredoxins keep the peroxiredoxins (Prx) reduced , thereby supporting their peroxidase function
Mitozo et al., Free Radic Biol Med 2011 : Impairing the thioredoxin (Trx) dependent peroxiredoxin (Prx) recycling by thioredoxin reductase (TrxR) inhibition with auranofin neither potentiated peroxide toxicity nor decreased the peroxide-decomposition rate