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IFNG — PTGS2
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Perkins et al., J Leukoc Biol 1999
:
LPS and
IFN-gamma induced
COX-2 protein expression was not decreased in cultures treated with AG for 2 h, illustrating that AG does not inhibit the formation of COX-2 protein
Matsuura et al., J Biol Chem 1999
(Carcinoma, Squamous Cell) :
Regulation of
cyclooxygenase-2 by
interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells ... Activation of the epidermal growth factor receptor (EGFR) signaling pathway due to the enhanced transforming growth factor alpha ( TGFalpha ) expression plays an important role in the
induction of
COX-2 by
IFN-gamma ... This is supported by the ability of TGFalpha to rapidly induce COX-2 and the inhibition of the
IFN-gamma mediated
COX-2 mRNA induction by an EGFR antibody and EGFR-selective kinase inhibitors
Mutoh et al., Carcinogenesis 2000
(Adenocarcinoma...) :
Interferon gamma suppressed this
COX-2 promoter activity, while 12-O-tetradecanoylphorbol-13-acetate and transforming growth factor alpha ( TGFalpha ) exerted enhancing effects
Mei et al., FASEB J 2000
:
We found that the
induction of
PGHS-2 and generation of PGE2 in these cells by
IFN-gamma and lipopolysaccharide (LPS) were greatly reduced by two selective NOS II inhibitors, L-NIL and SMT. To ascertain the effect of NO on PGHS-2 overexpression, we tested NO-releasing compounds, NOR-1 and SNAP, and found that they caused PGHS-2 expression and PGE2 production
Hayashi et al., Cytokine 2000
:
These results indicate that IL-1beta induced delayed PGE ( 2 ) generation in these human fibroblasts mainly depends on de novo induction of
COX-2 and cPLA(2), irrespective of the constitutive presence of COX-1, and that
IFN-gamma and IL-4
inhibit IL-1beta induced delayed PGE ( 2 ) generation by suppressing, predominantly, COX-2 expression
Blanco et al., J Exp Med 2000
(Shock, Septic) :
Interferon regulatory factor (IRF)-1 and IRF-2 regulate
interferon gamma dependent
cyclooxygenase 2 expression ... In this study, we demonstrate that
interferon (IFN)-gamma alone or in synergy with lipopolysaccharide (LPS) or interleukin 1alpha
induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E ( 2 ) ( PGE ( 2 ) ) release
Giroux et al., J Immunol 2000
:
Whereas LPS induced COX-2 mRNA and protein expression were down-regulated in DN PKC-alpha overexpressing clones,
IFN-gamma induced
COX-2 expression was up-regulated in DN PKC-alpha overexpressing clones with respect to normal RAW 264.7 cells ... Taken together, these results suggest a role for PKC-alpha in the modulation of LPS- and
IFN-gamma induced
COX-2 expression, as well as in IFN-gamma induced PGE2 secretion
Whan Han et al., Br J Pharmacol 2001
:
Ergolide inhibited nuclear factor-kappaB (NF-kappaB) activation, a transcription factor necessary for iNOS and
COX-2 expression in
response to
LPS/IFN-gamma
Yamada et al., Clin Exp Immunol 2002
(Urinary Bladder Neoplasms) :
NS398, a specific COX-2 inhibitor, and indomethacin ( IM ), a COX-1 and
COX-2 inhibitor,
enhanced viable BCG induced cytotoxic activity and
IFN-gamma and TNF-alpha production of PEC
Murakami et al., Carcinogenesis 2002
(Adenocarcinoma...) :
The combined lipopolysaccharide- and
interferon-gamma stimulated protein expressions of inducible nitric oxide synthase and cyclooxygenase
(COX)-2 , together with the release of tumor necrosis factor-alpha, in RAW 264.7 mouse macrophages were also markedly diminished
Basu et al., Glia 2002
(Brain Injuries...) :
These studies demonstrated that IL-1beta, TNFalpha, IL-6, but not
IFN-gamma increase the expression of
Cox-2 , whereas they all increase the expression of HCK and FAK
Raso et al., Br J Pharmacol 2002
:
Leptin potentiates
IFN-gamma induced expression of nitric oxide synthase and
cyclo-oxygenase-2 in murine macrophage J774A.1
Zhang et al., J Endotoxin Res 2002
:
Although previous studies have implicated two DNA binding proteins, interferon regulatory factor (IRF)-1 and IRF-2, in the regulation of LPS- and
IFN-gamma induced
COX-2 , their effects in vivo and in vitro are not well defined
Janicke et al., Res Vet Sci 2003
:
Lipopolysaccharide and
interferon gamma activate nuclear factor kappa B and
induce cyclo-oxygenase-2 in equine vascular smooth muscle cells
Kim et al., J Immunol 2003
(Inflammation) :
In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or
IFN-gamma stimulated induction of
cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes
Timoshenko et al., Int J Cancer 2004
(Mammary Neoplasms, Experimental) :
Both nonselective and selective
COX-2 inhibitors
suppressed IFN-gamma + LPS induced NO production, which was largely restored by exogenous PGE ( 2 ) or EP ( 4 ) receptor agonist PGE ( 1 ) alcohol
Chae et al., Immunopharmacol Immunotoxicol 2004
:
Salicylate treatment inhibited
COX-2 expression
induced by
TNF-alpha/IFN-gamma and regulated the activation of ERK, IKK and IkappaB degradation and subsequent NF-kappaB activation in MC3T3E1 osteoblasts
Hanna et al., Am J Reprod Immunol 2004
(Obstetric Labor, Premature) :
IFN-gamma mediated inhibition of
COX-2 expression in the placenta from term and preterm labor pregnancies ... The aim of this study was to evaluate the
effects of
interferon (IFN)-gamma on the expression of Cyclooxygenase
(COX)-2 and production of prostaglandin E ( 2 ) ( PGE ( 2 ) ) in the human placenta from term and preterm labor deliveries ...
IFN-gamma significantly
inhibited COX-2 expression and PGE ( 2 ) release in cultured placental explants from term and preterm labor deliveries ... Our data suggest that the human placenta is an important site for
IFN-gamma mediated repression of
COX-2 expression and PGE2 production, implying that functional withdrawal of IFN-gamma may be involved in the onset of term or preterm labor
Stamp et al., J Rheumatol 2004
:
Paracrine upregulation of monocyte
cyclooxygenase-2 by mediators produced by T lymphocytes :
role of interleukin 17 and
interferon-gamma
Janabi et al., J Neuroimmunol 2004
(Glioma) :
Differential
effects of
interferon-gamma on the expression of
cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes ... We compared
effects of
interferon-gamma (IFNgamma) on
cyclooxygenase-2 (COX-2) expression in malignant human glioma cell lines and cultured primary human astrocytes ... While
IFNgamma inhibited interleukin-1beta (IL1beta) induced expression of
COX-2 in the glioma cells, it enhanced expression in primary astrocytes ... This inhibitory
effect of
IFNgamma on expression of
COX-2 in human glioma cells may have relevance for immunotherapies directed against high-grade gliomas
Shibata et al., J Leukoc Biol 2005
:
In the
presence of LPS and
IFN-gamma ,
PGHS-2 expression and PGE2 release by IL-10 ( -/- ) and Balb/c splenic MO were enhanced compared with stimulation with LPS alone or IFN-gamma alone
Kim et al., Biochem Biophys Res Commun 2005
:
Protein expression of inducible nitric oxide synthase and
cyclooxygenase-2 , and production of NO by these cells were
induced by LPS or
IFN-gamma
Vila-del Sol et al., J Immunol 2005
:
IFN-gamma induces cyclooxygenase
(COX)-2 expression and PG production in mouse macrophage cells ...
IFN-gamma activates
COX-2 promoter-driven transcription ... In this region a NF-kappaB site has been described and mutation of this site impairs the
induction of the full
COX-2 promoter by
IFN-gamma ... Moreover,
IFN-gamma induction of the
COX-2 promoter was also strongly reduced by transfection of plasmid encoding the NF-kappaB inhibitor, IkappaBalpha ... Interestingly,
IFN-gamma induction of the COX-2 and PGE ( 2 ) synthesis was absent in macrophages from TNF ( -/- ) mice, and neutralizing anti-TNF Abs
inhibited COX-2 promoter induction by IFN-gamma in RAW 264.7 macrophages
Dinkova-Kostova et al., Proc Natl Acad Sci U S A 2005
(Inflammation) :
A series of synthetic triterpenoid ( TP ) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the
induction by
IFN-gamma of inducible nitric oxide synthase (iNOS) and of
cyclooxygenase 2 in mouse macrophages
Sheu et al., Cell Signal 2005
(Inflammation) :
LPS/IFN-gamma induced
COX-2 expression in mesangial cells could be inhibited by iNOS inhibitor, aminoguanidine
Hamby et al., J Neurosci Methods 2006
:
Purified monolayers appeared morphologically normal 24h after LME treatment and expressed nitric oxide synthase-2 (NOS-2) and
cyclooxygenase-2 (COX-2) proteins upon
stimulation with LPS plus
IFNgamma , albeit to a lower level than unpurified monolayers
Han et al., Endocrinology 2006
(Graves Ophthalmopathy) :
In addition,
interferon gamma inhibits IL-1beta provoked
PGHS-2 mRNA stability
Deng et al., Blood 2006
:
LPS or LPS plus
interferon-gamma (IFNgamma) increased binding of all 5 isoforms of NF-kappaB to
COX-2 and iNOS promoters
Matheus et al., Eur J Pharmacol 2007
:
We designed to investigate the inhibitory effect of isatin derivatives on
lipopolysaccharide/interferon-gamma induced expression of inducible nitric oxide synthase (iNOS) and
cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E ( 2 ) ( PGE ( 2 ) ), nitric oxide ( NO ), tumor necrosis factor ( TNF-alpha ), and their capacity to scavenge NO
Uto et al., Oncol Rep 2007
:
IFN-gamma did not induce any activation of these factors, but 6-MITC
suppressed IFN-gamma induced
COX-2 expression, suggesting that the upstream region of the core element is linked for this suppression ... These results suggest that LPS,
IFN-gamma and TPA
regulate COX-2 expression through different mechanisms, and 6-MITC acts as a potent inhibitor of COX-2 expression induced by LPS or IFN-gamma
Hayashi et al., J Immunol 2007
(Acute Disease...) :
Indeed,
IFN-gamma acetylated Stat1 and reciprocally
reduced NF-kappaB activation and
COX-2 expression in neutrophils
Taubert et al., Vet Res Commun 2008
:
Furthermore,
IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1, CXCL8, CCL5,
COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Deng et al., Arterioscler Thromb Vasc Biol 2007
:
Interferon-gamma suppresses
cyclooxygenase-2 promoter activity by inhibiting C-Jun and C/EBPbeta binding ... We postulated that
IFNgamma suppresses
COX-2 expression at the transcriptional level ... The
effect of
IFNgamma on
COX-2 expression was evaluated in several types of human cells stimulated with phorbol 12-myristate 13-acetate ( PMA ), interleukin (IL)-1beta, or tumor necrosis factor (TNF) alpha ...
IFNgamma suppresses proinflammatory mediator induced
COX-2 transcription by selective inhibition of C-Jun and C/EBPbeta DNA binding activity and p300 recruitment in human cells
Esposito et al., J Pineal Res 2008
:
Moreover, Western blot analysis showed that melatonin inhibited
LPS/IFN-gamma induced expression of
COX-2 protein, but not that of constitutive cyclooxygenase
Boost et al., BMC cancer 2008
(Lung Neoplasms...) :
In contrast to IL-8, IL-1beta induced
cyclooxygenase-2 expression and release of IL-6 were not
affected by
IFNgamma indicating that modulation of IL-1beta action by this cytokine displays specificity
Martinet et al., Eur J Immunol 2009
:
COX-2 expression and PGE ( 2 ) production by MSC were not constitutive, but were
induced by
IFN-gamma and TNF-alpha secreted by activated Vgamma9Vdelta2 T cells
Lee et al., Biocell 2009
:
Particularly,
interferon gamma (IFNgamma) induced
COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases ... Based on the above description, we compared the effect of simvastatin on
IFNgamma induced
COX-2 expression in human monocytes versus murine macrophages ... In a result, we found that simvastatin suppresses
IFNgamma induced
COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNgamma induced COX-2 expression in murine RAW264.7 macrophages ... Our findings showed that simvastatin is likely to suppress
IFNgamma induced
COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells ... Thus, we concluded that
IFNgamma induced
COX-2 expression is differently regulated by simvastatin depending on species specific mechanism
Misko et al., J Neuroimmunol 1995
(Encephalomyelitis, Autoimmune, Experimental...) :
Mediation of inflammation by encephalitogenic cells :
interferon gamma induction of nitric oxide synthase and
cyclooxygenase 2
Riese et al., J Leukoc Biol 1994
:
In the
presence of
IFN-gamma and LPS,
PGHS-2 mRNA expression reached a maximum at 8 h but PGHS-1 mRNA was not induced during the whole time period
Endo et al., J Immunol 1996
:
LPS dependent
cyclooxygenase-2 induction in human monocytes is
down-regulated by IL-13, but not by
IFN-gamma
Pang et al., Br J Pharmacol 1997
:
Effect of interleukin-1 beta, tumour necrosis factor-alpha and
interferon-gamma on the induction of
cyclo-oxygenase-2 in cultured human airway smooth muscle cells
von Knethen et al., FASEB J 1997
:
Our results point to
cyclooxygenase-2 induction by
lipopolysaccharide/interferon gamma/N(G)-monomethyl-L-arginine or low-dose nitric oxide pretreatment conferring macrophage protection to the apoptotic action of nitric oxide
Moos et al., J Immunol 1999
:
Taxol alone or taxol plus
IFN-gamma increased PGE2 formation,
PGHS-2 protein expression, and PGHS-2 mRNA expression in RAW 264.7 murine macrophages