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CDK5 — RAC1

Text-mined interactions from Literome

Alexander et al., Mol Cell Biol 2004 : The increased activity of CDK5 further reduces GTPase Rac1 activity and Pak activation ... The repression of the activity of the GTPase Rac1 by CDK5 is required for expression of the senescent phenotype ... CDK5 regulation of Rac1 activity is necessary for actin polymerization accompanying senescent morphology in response to expression of pRb, activated Ras, or continuous passage
Castillo-Lluva et al., J Cell Sci 2007 : Our results indicated that Cdk5 is required for the activity of Rac1 , probably at the level of the localization of its GEF, Cdc24. Cdk5 was required for full virulence, probably because mutant cells are unable to sustain the dramatic polar growth required for the formation of the infective structures