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GAB1 — JUN
Text-mined interactions from Literome
Che et al., Circ Res 2002
:
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells :
role of
Gab1 and MEKK3 in TNF-alpha induced
c-Jun and NF-kappaB activation and adhesion molecule expression ... Because
Gab1 is
involved in both
c-Jun and NF-kappaB activation by TNF-alpha, we focused on Gab1 dependent signaling ... Interestingly,
Gab1 inhibited
c-Jun transcriptional activity induced by MEKK3 but not MEKK1 and MEK4 ...
Gab1 associated with MEKK3, and a catalytically inactive form of MEKK3
inhibited TNF-alpha induced
c-Jun and NF-kappaB transcriptional activation, suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003
(Inflammation) :
Because MEKK3 and
Gab1 are
critical for TNF-alpha induced
c-Jun and NF-kappaB activation, we determined the role of SHP-2 phosphatase activity in MEKK3 signaling ... A catalytically inactive form of SHP-2 increased
MEKK3/Gab1 interaction and
inhibited MEKK3 ( but not MEKK1 ) -mediated
c-Jun and NF-kappaB activation
Sun et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
Role of
Gab1 in UV-induced
c-Jun NH2-terminal kinase activation and cell apoptosis