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PARP1 — RASGRP2
Text-mined interactions from Literome
Eto et al., Proc Natl Acad Sci U S A 2002
:
On the other hand, retroviral expression of
CalDAG-GEFI , a Rap1 exchange factor identified by megakaryocyte gene profiling as a candidate integrin regulator,
enhanced agonist induced activation of
Rap1b and fibrinogen binding to alphaIIbbeta3 ( P < 0.01 )
Katagiri et al., J Biol Chem 2004
:
Furthermore, when expressed in Jurkat cells,
CalDAG-GEFI , a calcium and diacylglycerol-responsive Rap1 exchange factor, associated with Rap1, and
resulted in enhanced
Rap1 activation and adhesion triggered by the TCR
Caloca et al., J Biol Chem 2004
:
Finally, we show that the
RasGRP2/F-actin interaction
promotes the regionalized activation of
Rap1 in juxtamembrane areas of the cell
Regier et al., Proc Natl Acad Sci U S A 2005
(Neoplasms, Experimental) :
In addition to activating Ras,
RasGRP3 also
activates Rap1 , which in some cases can antagonize the function of Ras
Carbo et al., J Leukoc Biol 2010
:
Interestingly, Rap1b-/- neutrophils had a similar phenotype in this assay, suggesting that
CalDAG-GEFI may be
acting through
Rap1b
Stadtmann et al., Eur J Immunol 2011
(Peritonitis) :
Rap1a activation by
CalDAG-GEFI and p38 MAPK is involved in E-selectin dependent slow leukocyte rolling ... Our data demonstrate that
Rap1a activation by p38 MAPK and
CalDAG-GEFI is involved in E-selectin dependent slow rolling and leukocyte recruitment
Takino et al., Cell Adh Migr 2013
:
Furthermore,
RasGRP2 overexpression
increased Rap1 activation and cell-matrix adhesion in ECV304 cells
Guidetti et al., Biochem J 2013
:
In transfected HEK ( human embryonic kidney ) -293 cells, as well as in platelets, forskolin induced phosphorylation of
CalDAG-GEFI prevented the activation of
Rap1b induced by the Ca2+ ionophore A23187
Subramanian et al., Journal of thrombosis and haemostasis : JTH 2013
(Calcium Signaling) :
Phosphorylation of
CalDAG-GEFI by protein kinase A
prevents Rap1b activation
Kawasaki et al., Proc Natl Acad Sci U S A 1998
:
Expression of
CalDAG-GEFI activates
Rap1A and inhibits Ras dependent activation of the Erk/MAP kinase cascade in 293T cells