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MMP24 — PLG
Text-mined interactions from Literome
Ramos-DeSimone et al., J Biol Chem 1999
(Neoplasm Invasiveness) :
When the MMP-9/TIMP ratio exceeds 1.0,
MMP-9 activation progresses, but through an interacting protease cascade
involving plasmin and stromelysin 1 ( MMP-3 )
Balcerzak et al., J Anim Sci 2001
:
The
MMP are
regulated at the levels of transcription, zymogen activation by
plasmin or membrane-type- ( MT ) MMP, and control of enzyme activity by tissue inhibitors of metalloproteinases ( TIMP )
Hosomi et al., Stroke 2001
(Acute Disease...) :
Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of
plasmin or by
MMP activation
Monea et al., J Cell Physiol 2002
:
Thus,
plasmin can activate proMMP-2 only in the
presence of
MT1-MMP ; however, this process does not require the catalytic activity of MT1-MMP
May et al., Thromb Haemost 2005
(Arteriosclerosis) :
We studied the effect of E-LDL on the activation of
plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on
MMP activation during cellular interactions
Stempien-Otero et al., J Biol Chem 2006
(Fibrosis) :
We did not detect
plasmin mediated
activation of TGF-beta1,
MMP-2 , or MMP-9 in hearts of SR-uPA+/o mice
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2010
:
Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM accumulation in part through suppression of
plasmin generation and
matrix metalloproteinase ( MMP ) activation
Ghosh et al., J Cell Physiol 2012
(Fibrosis) :
During wound healing, elevated levels of PAI-1 inhibit uPA/tPA/plasmin and
plasmin dependent
MMP activities, and, thus, help expedite wound healing