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FOXO4 — PRKAA1
Text-mined interactions from Literome
Greer et al., Curr Biol 2007
:
Lastly, we find that AMPK activates FOXO/DAF-16 dependent transcription and phosphorylates FOXO/DAF-16 at previously unidentified sites, suggesting a possible direct mechanism of
regulation of
FOXO/DAF-16 by
AMPK
Nystrom et al., International journal of clinical and experimental medicine 2008
:
Our data indicate
FoxO mRNA expression is
down-regulated by
AMPK activation and energy depletion in cultured myotubes, but that a contrasting increase in FoxO1 and FoxO3 mRNA is observed in vivo with the agent ( and in response to sepsis ) suggesting the expression of these FoxOs may be controlled by other hormonal or energy sensing cues under in vivo conditions
Greer et al., Ann N Y Acad Sci 2009
:
AMPK phosphorylation
enhances FoxO transcriptional activity, leading to the expression of specific target genes involved in stress resistance and changes in energy metabolism
Vadlakonda et al., Frontiers in oncology 2013
:
Depletion of energy leads to inactivation of mTORC1,
activation of
AMPK ,
FoxO , and promotes constitution of mTORC2 that leads to phosphorylation of Akt S473