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CTCF — IGF2
Text-mined interactions from Literome
Yang et al., J Cell Biochem 2003
:
In this study, we examined the allelic DNA methylation and CTCF binding in the Igf2/H19 imprinting center in CNS, hypothesizing that the aberrant
CTCF binding as one of the mechanisms
leads to biallelic expression of
Igf2 in CNS
Fu et al., J Biol Chem 2004
:
The forced down-regulation of
CTCF expression using small interfering RNA in imprinted prostate cell lines
resulted in an increase in
IGF2 expression and a relaxation of imprinting
Kurukuti et al., Proc Natl Acad Sci U S A 2006
:
CTCF binding in the maternal ICR
regulates its interaction with matrix attachment region ( MAR ) 3 and DMR1 at
Igf2 , thus forming a tight loop around the maternal Igf2 locus, which may contribute to its silencing
Li et al., Mol Cell Biol 2008
:
CTCF regulates allelic expression of
Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
Zhang et al., J Cell Biol 2011
:
Monoallelic expression of
IGF2 is
regulated by
CCCTC binding factor (CTCF) binding to the imprinting control region ( ICR ) on the maternal allele, with subsequent formation of an intrachromosomal loop to the promoter region