Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Wang et al., Mol Cell Biol 2001 : Cyclin D1 repression was independent of IKK , as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1
Song et al., Biochim Biophys Acta 2010 (MAP Kinase Signaling System) : Notably, IKKa dependent Cyclin D1 regulation is unrelated to IKKbeta/NF-kappaB activity ... We further show that IKKalpha dependent downregulation of Cyclin D1 expression in the UVB response results from the reduction of ERK1/2 dependent Cyclin D1 transcription coupled with an increase of p38 kinase dependent Cyclin D1 proteolysis