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RAC1 — VCAM1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 185 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Intact Interaction: Complex of 177 proteins (association, cross-linking study) Byron et al., Proteomics 2012
• IRef Intact Interaction: Complex of 203 proteins (association, cross-linking study) Byron et al., Proteomics 2012

Text-mined interactions from Literome

Chen et al., J Pharmacol Exp Ther 2003 : In contrast, Ad.N17Rac1 inhibited TNF-alpha induced NF-kappaB-driven HIV ( kappaB ) ( 4 ) -CAT and p288VCAM-Luc promoter activity, suggesting that N17Rac1 inhibits TNF-alpha induced VCAM-1 , E-selectin, and ICAM-1 through suppressing NF-kappaB mediated transactivation
Cook-Mills et al., Biochem J 2004 (Calcium Signaling) : Calcium mobilization and Rac1 activation are required for VCAM-1 ( vascular cell adhesion molecule-1 ) stimulation of NADPH oxidase activity ... Furthermore, VCAM-1 specifically activated the Rho-family GTPase Rac1, and VCAM-1 activation of NADPH oxidase was blocked by a dominant negative Rac1
Marchese et al., Biochemistry 2012 : In contrast, S730 and S737, but not S728 or Y729, were necessary for VCAM-1 activation of Rac1 ... Together, these data indicate that S728 and Y729, and S730 and S737, are distinct functional sites that coordinate VCAM-1 activation of calcium fluxes and Rac1 during leukocyte transendothelial migration
Wu et al., Biochem Pharmacol 2013 (Inflammation) : The Rac-1 activation and ROS liberation mediated TNF stimulated NF-?B activation and the subsequent VCAM-1 and ICAM-1 expression