Gene interactions and pathways from curated databases and text-mining

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IRF6 — TXN

Text-mined interactions from Literome

Ejima et al., Placenta 1999 : In this study, to investigate further the roles of thioredoxin and thioredoxin reductase in protecting pregnancy against oxidative stress, we examined the effect of lipopolysaccharide (LPS) , which induces a variety of cytokines and produces radical oxygen species, on the expression of thioredoxin and thioredoxin reductase in mouse placenta
Francisco et al., Arch Dermatol Res 2010 : We verified that LPS induced upregulation of thioredoxin-1 expression was dependent on PI3K pathway
Yuan et al., Free Radic Biol Med 2010 : Aminoguanidine, a competitive glycation-inhibitor, completely blocked the inhibitory effect of LPS on Trx-1
Hsiang et al., Food Chem 2013 (Inflammation) : Microarray analysis revealed that biological pathways associated with metabolism and the immune responses were affected by TS or GA. Particularly, LPS induced thioredoxin-like 4B (TXNL4B) 2 expression in the small intestine, and TXNL4B, iNOS, and COX-2 expression in RAW 264.7 cells were significantly inhibited by TS or GA