Zhu et al., J Biol Chem 2003
:
Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP Mudter et al., Inflamm Bowel Dis 2011
(Colitis...) :
In contrast to DSS colitis, IRF4 deficiency was protective in T-cell dependent transfer colitis associated with reduced RORa/?t levels and impaired IL-6 , IL-17a, and IL-22 production, suggesting that IRF4 acts as a master regulator of mucosal Th17 cell differentiation
Harroch et al., J Biol Chem 1993
:
The dissociation between induction of mRNAs and of protein binding observed suggests that the activity of the IRF proteins is regulated by IL-6