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IL6 — JAK3
Pathways - manually collected, often from reviews:
-
BioCarta role of erbb2 in signal transduction and oncology:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3)
→
STAT3
(modification, activates)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
STAT3
(modification, activates)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
JAKs (JAK2/JAK1/JAK3)
(modification, collaborate)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
(modification, collaborate)
-
BioCarta il 6 signaling pathway:
JAKs (JAK2/JAK1/JAK3)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
(modification, collaborate)
-
BioCarta role of erbb2 in signal transduction and oncology:
JAKs (JAK2/JAK1/JAK3)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
(modification, collaborate)
-
BioCarta role of erbb2 in signal transduction and oncology:
JAKs (JAK2/JAK1/JAK3)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3)
(modification, collaborate)
-
BioCarta role of erbb2 in signal transduction and oncology:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC)
→
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3)
(modification, collaborate)
-
BioCarta il 6 signaling pathway:
IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
Text-mined interactions from Literome
Wang et al., Oncogene 2000
:
PD180970 did not affect MAPK activation by PDGF or the
JAK dependent
activation of Stat3 by
interleukin-6
Song et al., Zhonghua Xue Ye Xue Za Zhi 2000
(Multiple Myeloma) :
The biological function of
IL-6 on Sko-007 cells is
mediated by the activation of
Jak/STAT and Ras/NF-IL-6 signal transduction pathways
Kuo et al., Oncogene 2001
:
In Hep3B cells, the
JAK/STAT3 , ERK, and PI 3-K/Akt pathways were
activated by
IL-6 stimulation
Song et al., Zhonghua Zhong Liu Za Zhi 2001
(Multiple Myeloma) :
( 1 ) IL-6 could promote the proliferation of U266 cells, ( 2 ) both
JAK/STAT and Ras/NF-IL-6 signal transduction pathways were
activated by
IL-6 in the U266 cells and ( 3 ) Cell proliferation and activation of the two IL-6 signal transduction pathways were inhibited by Forskolin ; down regulating the actiration of these two signal transduction pathways at the same time
Legendre et al., J Biol Chem 2003
:
JAK/STAT but not ERK1/ERK2 pathway
mediates interleukin (IL)-6/soluble
IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes
Mangan et al., Blood 2004
:
Mechanisms associated with
IL-6 induced up-regulation of
Jak3 and its role in monocytic differentiation
Siavash et al., Br J Cancer 2004
(Carcinoma, Squamous Cell...) :
Abrogation of
IL-6 mediated
JAK signalling by the cyclopentenone prostaglandin 15d-PGJ ( 2 ) in oral squamous carcinoma cells ... Importantly, 15d-PGJ ( 2 ) selectively abrogated constitutive and
IL-6 mediated
JAK phosphorylation without affecting EGFR activated levels ... Our findings provide the first evidence for 15d-PGJ ( 2 ) -mediated downregulation of constitutive and
IL-6 induced
JAK signalling in cancer and support that JAK inhibition and suppression of EGFR independent Stat3 activation by 15d-PGJ ( 2 ) represent a promising approach for induction of apoptosis in oral SCC cells
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Kimura et al., Proc Natl Acad Sci U S A 2005
:
Suppressor of cytokine signaling-1 selectively
inhibits LPS induced
IL-6 production by regulating
JAK-STAT
Lee et al., Mol Cancer Ther 2006
(Carcinoma, Squamous Cell...) :
We conclude that SOCS-1 methylation status can differentially affect STAT3
activation by
IL-6R and EGFR through
JAK or MEK in different HNSCC and response to pharmacologic antagonists
O'Hara et al., Biochem J 2007
:
Inhibition with siRNA ( small interfering RNA ) targeting the SFK Lck, but not dominant negative
JAK ( Janus kinase ),
prevented Cr ( VI ) -stimulated phosphorylation of both STAT3 isoforms and induction of
IL-6
Gong et al., Mol Nutr Food Res 2009
(Prostatic Neoplasms) :
Moreover, an antioxidant reagent, N-acetyl-L-cysteine (NAC) which suppresses reactive oxygen species ( ROS ) generation, reversed the early inhibitory effects of PEITC on cell proliferation, constitutive or
IL-6 mediated
JAK-STAT3 phosphorylation in PCa cells
Radtke et al., J Cell Sci 2010
:
We show that p38, activated by IL-1beta, TNFalpha or environmental stress, impairs
IL-6 induced
JAK/STAT signalling through phosphorylation of the common cytokine receptor subunit gp130 and its subsequent internalisation and degradation
Tanabe et al., Journal of neuroinflammation 2010
(Glioma) :
The
Janus family of tyrosine kinase ( JAK ) inhibitor I, an inhibitor of JAK 1, 2 and 3, attenuated TNF-alpha induced phosphorylation of STAT3 and significantly
reduced TNF-alpha stimulated
IL-6 release
Liu et al., Neurotox Res 2011
:
These results suggest that
IL-6 protects neurons against NMDA induced apoptosis, and that the IL-6 neuroprotection is jointly
mediated by
JAK-STAT3 and PI3K-Akt signaling pathways
Ngo et al., Nature 2011
(Burkitt Lymphoma...) :
The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-?B signalling,
JAK kinase
activation of STAT3, and secretion of
IL-6 , IL-10 and interferon-ß
Tanabe et al., Journal of neuroinflammation 2011
:
The IL-1ß stimulated levels of
IL-6 were
suppressed by wedelolactone ( an inhibitor of I?B kinase ), SP600125 ( an inhibitor of SAPK/JNK ), and
JAK inhibitor I ( an inhibitor of JAK 1, 2 and 3 )
Dittrich et al., Molecular bioSystems 2012
:
Misregulated
interleukin-6 (IL-6) induced
Jak/STAT signaling contributes to many diseases
Nam et al., J Pept Sci 2012
:
Inhibition of
JAK ( STAT1/STAT5 kinase ) with AG490 markedly
reduced the production of
IL-6 and TNF-a in macrophages
Russell et al., Islets 2013
:
Differential
effects of interleukin-13 and
interleukin-6 on
Jak/STAT signaling and cell viability in pancreatic ß-cells
Lai et al., PloS one 2013
:
Additionally,
IL-6 mediated angiotensinogen expression through the Janus kinase ( JAK ) /signal transducer and activator of transcription 3 ( STAT3 ) and
JAK/p38 signaling ...
IL-6 mediated signaling,
JAK2 , STAT3 and p38 inhibitors reduced angiotensinogen expression in the partially hepatectomized mice
Leven et al., Blood Cells Mol Dis 1997
:
Studies on protein phosphorylation revealed that
IL6 , but not TPO,
stimulated phosphorylation of JAK1,
JAK2 and MAP kinase
Sengupta et al., Proc Natl Acad Sci U S A 1998
:
These results demonstrate an ERK mediated mechanism for inhibiting
IL-6 induced
Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway