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MALT1 — RELA
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
Complex of BCL10-CARD9-MALT1
→
NFKB1/RELA
(protein-protein, activation)
Text-mined interactions from Literome
Vega et al., Adv Anat Pathol 2001
(Lymphoma, B-Cell, Marginal Zone...) :
Recent work suggests that
API2-MALT1 and BCL-10-MALT1 may
activate NF-kB and a common downstream signaling pathway
Che et al., J Biol Chem 2004
(Lymphoma, B-Cell, Marginal Zone) :
MALT1/paracaspase is a signaling component downstream of CARMA1 and
mediates T cell receptor induced
NF-kappaB activation ... Expression of a
MALT1 deletion mutant containing only the N-terminal death domain and the two Ig-like domains completely
blocked CD3/CD28 costimulation induced, but not tumor necrosis factor-alpha induced,
NF-kappaB activation
Lynch et al., Mol Interv 2004
:
Overexpression of
MALT1 , as observed in a subset of lymphoma patients,
leads to the potent activation of
NF-kappaB , suggesting that MALT1 might stimulate ( directly or indirectly ) the kinase complex [ IKK, inhibitor of NF-kappaB (IkappaB) kinase ] responsible for activating cytoplasmic NF-kappaB for translocation into the nucleus
Hosokawa et al., Int J Hematol 2004
(Lymphoma, B-Cell, Marginal Zone) :
Recent genetic and biochemical studies have indicated that BCL10 and
MALT1 form a physical and functional complex and are both
essential for
nuclear factor kappaB (NF-kappaB) activation by antigen receptor stimulation in lymphocytes ... BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation can be assumed to be able to contribute to antiapoptosis, probably through NF-kappaB mediated up-regulation of several apoptotic inhibitor genes
Ho et al., Blood 2005
(Lymphoma, B-Cell...) :
API2-MALT1 and exogenous MALT1
increased constitutive
NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation
Ye et al., J Pathol 2005
(Lymphoma, B-Cell, Marginal Zone...) :
The oncogenic activity of the three chromosomal translocations is linked by the physiological
role of BCL10 and
MALT1 in antigen receptor mediated
NFkappaB activation
Hosokawa et al., Apoptosis 2005
(Lymphoma, B-Cell, Marginal Zone...) :
This stability of
API2-MALT1 may thus
result in inappropriate
nuclear factor (NF)-kappaB activation, thereby contributing to the pathogenesis of MALT lymphoma ... Recent biochemical and genetic studies have clearly shown that BCL10 and
MALT1 form a physical and functional complex and are both
required for
NF-kappaB activation by antigen receptor stimulation in T and B lymphocytes ... Furthermore, BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation may contribute to anti-apoptotic action probably through NF-kappaB mediated upregulation of apoptotic inhibitor genes
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
While both BCL10 and
MALT1 are critically
involved in antigen receptor mediated
NF-kappaB activation, the role of cIAP2 is not clear ... Furthermore, BCL10 and
cIAP2-MALT1 synergistically
activate NF-kappaB
Zhou et al., Br J Haematol 2006
(Lymphoma, B-Cell, Marginal Zone...) :
t ( 11 ; 18 ) ( q21 ; q21 ) occurs specifically in mucosa associated lymphoid tissue ( MALT ) lymphoma and the translocation generates a functional
API2-MALT1 fusion product that
activates nuclear factor (NF)kappaB
Nakagawa et al., Leukemia 2006
(Lymphoma, B-Cell, Marginal Zone) :
Several lines of evidence indicated that both BCL10 and
MALT1 are
required for
nuclear factor kappa B (NF-kappaB) activation by antigen receptor stimulation in lymphocytes, and API2-MALT1 can bypass this BCL10/MALT1 signaling pathway ... We recently demonstrated that
API2-MALT1 can
induce transactivation of the API2 gene through
NF-kappaB activation, thus highlighting a positive feedback-loop mechanism of self-activation by upregulating its own expression in t ( 11 ; 18 ) MALT lymphomas
Rivera et al., Trends Immunol 2006
:
The
CARMA1-Bcl10-Malt1 adaptor complex
regulates NFkappaB activation by antigen receptors in lymphocytes
Hu et al., Cell cycle (Georgetown, Tex.) 2006
:
Furthermore,
cIAP2-MALT1 and Bcl10 synergistically
activate NF-kappaB
Gross et al., Nature 2006
:
Card9 couples to Bcl10 and regulates
Bcl10-Malt1 mediated
NF-kappaB activation induced by zymosan
Klemm et al., Proc Natl Acad Sci U S A 2007
:
Bcl10 and
Malt1 control lysophosphatidic acid induced
NF-kappaB activation and cytokine production ... By using murine embryonic fibroblasts from Bcl10- or Malt1-deficient mice as a genetic model, we report that Bcl10 and
Malt1 are critically
required for the degradation of IkappaB-alpha and the subsequent
NF-kappaB induction in response to LPA stimulation
McAllister-Lucas et al., Proc Natl Acad Sci U S A 2007
(Inflammation) :
CARMA3/Bcl10/MALT1 dependent
NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
Jost et al., J Immunol 2007
:
Bcl10/Malt1 signaling is
essential for TCR induced
NF-kappaB activation in thymocytes but dispensable for positive or negative selection
Noels et al., J Biol Chem 2007
(Lymphoma, B-Cell, Marginal Zone...) :
Finally, binding of TRAF2 to BIR1 contributed to
NF-kappaB activation by
API2.MALT1 , although additional mechanisms involving BIR1 mediated raft association are also important
Lucas et al., Oncogene 2007
:
A dual role for the API2 moiety in
API2-MALT1 dependent
NF-kappaB activation : heterotypic oligomerization and TRAF2 recruitment ... Thus, API2 moiety mediated heterotypic oligomerization and TRAF2 binding both contribute to maximal
API2-MALT1 dependent
NF-kappaB stimulation
Wegener et al., Science's STKE : signal transduction knowledge environment 2007
:
CARD11 ( CARMA1 ), Bcl10, and
Malt1 are
required for nuclear factor
NF-kappaB activation in response to antigen recognition
Hara et al., Nat Immunol 2007
(Listeriosis) :
The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells ... The
CARMA1-Bcl-10-MALT1 complex is
critical for the activation of transcription factor
NF-kappaB in lymphocytes but has an unclear function in myeloid cells
Ferch et al., Nat Immunol 2007
:
Here we found that Bcl-10 and
MALT1 differentially regulated B cell receptor
induced activation of
RelA and c-Rel
Rebeaud et al., Nat Immunol 2008
:
In contrast,
MALT1 activity but not Bcl-10 cleavage was
essential for optimal activation of transcription factor
NF-kappaB and production of interleukin 2
Kingeter et al., J Immunol 2008
:
Loss of protein kinase C theta, Bcl10, or
Malt1 selectively
impairs proliferation and
NF-kappa B activation in the CD4+ T cell subset
Garrison et al., Oncogene 2009
:
Here, we investigated the role of TRAF2 in
c-IAP2/MALT1 induced
NF-kappaB activation ... Studies of
c-IAP2/MALT1 BIR1 mutant ( E47A/R48A ) that fails to
activate NF-kappaB showed loss of TRAF2 binding, but retention of TRAF6 binding, suggesting that interaction of c-IAP2/MALT1 with TRAF6 is insufficient for NF-kappaB induction ... Comparisons of the bioactivity of intact c-IAP2/MALT1 oncoprotein and BIR1 E47A/R48A c-IAP2/MALT1 mutant that can not bind TRAF2 in a lymphoid cell line provided evidence that TRAF2 interaction is critical for
c-IAP2/MALT1 mediated
increases in the
NF-kappaB activity, increased expression of endogenous NF-kappaB target genes ( c-FLIP, TRAF1 ), and resistance to apoptosis