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ADCYAP1 — GHRH

Pathways - manually collected, often from reviews:

• Reactome Reaction: ADCYAP1 → GHRH (reaction) Wenzel-Seifert et al., Biochem Pharmacol 2002, Zhang et al., Eur J Pharmacol 2003, Mitsuhashi et al., J Biol Chem 1989, Kozasa et al., Proc Natl Acad Sci U S A 1988, Baker et al., J Biol Chem 1998

Text-mined interactions from Literome

Wang et al., Domest Anim Endocrinol 2010 : Results showed that : ( 1 ) all receptors are G protein coupled receptors functionally coupled to the intracellular PKA signaling pathway ; ( 2 ) 2 GHRH receptors ( cGHRHR ( 1 ) and cGHRHR ( 2 ) ) were identified, and both receptors could be potently activated by cGHRH ; ( 3 ) cGHRH-LP could activate its specific receptor cGHRH-LPR ( cPRP-R ), and it also activated cGHRHR ( 1 ) and cGHRHR ( 2 ) ; and ( 4 ) PACAP could potently activate its receptors cPAC ( 1 ), cVPAC ( 1 ) and cVPAC ( 2 ) ; however, cVPAC ( 1 ) and cVPAC ( 2 ) could also be effectively activated by cVIP and tPHI, indicating that they can serve as VIP receptors and potential PHI receptors
Desai et al., J Clin Endocrinol Metab 1994 (Adenoma...) : The effects of PACAP38 were less potent than either GHRH on GH release in the somatotrope tumor or CRH on ACTH release in the corticotrope tumors but similar to the responses seen with the cAMP analog 8-bromo-cAMP ( 8-Br-cAMP )