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ADCYAP1 — NGF

Text-mined interactions from Literome

Hashimoto et al., J Neurochem 2000 : PACAP gene transcription was also induced by NGF ... The mitogen activated protein kinase extracellular signal regulated kinase ( ERK ) kinase 1/2 ( MEK1/2 ) inhibitor PD98059 also blocked the PACAP mRNA expression induced by either PACAP or NGF but not that induced by a combination of PACAP and NGF ... These results suggest that PACAP stimulates the PACAP gene expression in PC12 cells at least in part through activation of adenylate cyclase and protein kinase C signaling pathways and that the ERK1/2 cascade is involved in PACAP and NGF induced PACAP gene expression, although redundant signaling pathways may also be involved
Sakai et al., Biochem Biophys Res Commun 2001 : Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells ... We have recently shown that in PC12 cells, PACAP and NGF synergistically increase PACAP gene transcription and mRNA level, and that the MAPK/ERK kinase inhibitor PD98059 blocks the PACAP mRNA expression induced by either PACAP or NGF, but not that induced by the combination, suggesting involvement of multiple signaling pathways
Jongsma Wallin et al., Eur J Neurosci 2001 (Inflammation...) : NGF dramatically up-regulated PACAP expression in trkA positive neurons in both intact and injured DRGs, implicating NGF as a positive regulator of PACAP expression in nociceptive neurons
Lee et al., J Biol Chem 2002 : The activation of TrkA receptors by PACAP required at least 1 h of treatment and did not involve binding to nerve growth factor
Sakai et al., Regul Pept 2002 : We have recently shown that in PC12 cells, pituitary adenylate cyclase activating polypeptide ( PACAP ) and NGF synergistically stimulate PACAP mRNA expression primarily via a mechanism involving a p38 mitogen activated protein kinase ( MAPK ) -dependent pathway
Jongsma Wallin et al., Neuroscience 2003 (Neurogenic Inflammation) : This study examines the role of endogenous NGF in inflammation associated increases in PACAP expression using the adjuvant induced peripheral inflammation model with or without systemic administration of antibodies against NGF
Zhang et al., Cell Signal 2009 (MAP Kinase Signaling System) : Lithium and valproate promote but wortmannin and LY294002 attenuate PACAP induced phosphorylation of both GSK3beta and ERK1/2, whereas MEK inhibitor PD98059 inhibits nerve growth factor- but not PACAP induced phosphorylation of GSK3beta, suggesting that GSK3beta operates downstream of Rapt 1 but upstream of ERK1/2 in PACAP signalling
Przywara et al., J Neurochem 1998 : However, in neurons grown for 2 days with NGF and then deprived of NGF , PACAP prevented cell death for the next 24-48 h. Uptake of [ 3H ] norepinephrine ( [ 3H ] NE ) was used as an index of survival and decreased > 50 % in NGF deprived cultures within 24 h. PACAP ( 1-100 nM ) restored [ 3H ] NE uptake to 92 +/- 8 % of that of NGF supported controls