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ADCYAP1 — SST

Text-mined interactions from Literome

Zeng et al., J Clin Invest 1999 : PACAP and VIP stimulated calcium signaling and somatostatin release from D cells with almost equal efficacy
Lindström et al., Regul Pept 2001 : Somatostatin , prostaglandin E2 ( PGE2 ) and the PGE1 congener misoprostol inhibited PACAP- and gastrin stimulated secretion by more than 90 %, with IC ( 50 ) values ranging from 90-720 ( somatostatin ) to 40-200 ( misoprostol ) pM
Tornøe et al., Regul Pept 2001 : PACAP 1-38 ( 10 ( -8 ) M ) inhibited gastrin secretion and stimulated somatostatin secretion and motility dose-dependently
Braas et al., Neuroscience 2004 : The guinea-pig cardiac ganglia neurons express the high affinity pituitary adenylate cyclase activating polypeptide ( PACAP ) -selective PAC1 receptor, and treatment of the ganglia explants with 20 nM PACAP27 for 72 h to evaluate PACAP regulation of somatostatin expression revealed a dramatic 85 % decrease in the number of somatostatin-IR neurons ( 6 % somatostatin-IR neurons ) compared with untreated control explant preparations ... The PACAP27 mediated effect on somatostatin expression was not affected by inhibitors of protein kinase A or phospholipase C, but was reduced by the adenylyl cyclase inhibitor SQ22356, suggesting cAMP involvement
Németh et al., Neuroscience 2006 (Neurogenic Inflammation) : The maximal inhibitory effects of PACAP on capsaicin induced substance P, CGRP and somatostatin release amounted to 75.4 %, 73.3 % and 90.0 %, while EFS evoked release of these peptides was 80.03 %, 87.7 % and 67.7 %
Reglodi et al., J Mol Neurosci 2008 (MAP Kinase Signaling System) : In isolated rat tracheae, PACAP6-38 , similarly to PACAP1-38, induced significant inhibitory effects on the release of three simultaneously measured sensory neuropeptides, substance P, calcitonin gene related peptide, and somatostatin evoked by both chemical excitation and electrical field stimulation of capsaicin-sensitive afferents