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EGFR — HGS

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HGS → EGFR (increases, HGS Activity) Steen et al., J Biol Chem 2002*
  Evidence: Using anti-phosphotyrosine antibodies for immunoprecipitation and one-dimensional gel electrophoresis, we have identified 10 proteins in the epidermal growth factor receptor signaling pathway, of which 8 have been shown previously to be involved in epidermal growth factor signaling. Most importantly, in addition to several known tyrosine phosphorylation sites, we have identified five novel sites on SHIP-2, Hrs, Cbl, STAM, and STAM2, most of which were not predicted to be phosphorylated.
• Reactome Reaction: EGFR → HGS (indirect_complex) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
• Reactome Reaction: EGFR → HGS (reaction) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — HGS (direct interaction, pull down) Morino et al., Exp Cell Res 2004
• IRef Biogrid Interaction: EGFR — HGS (physical association, affinity chromatography technology) Meijer et al., Cell Signal 2013*
• IRef Biogrid Interaction: EGFR — HGS (physical association, affinity chromatography technology) Sun et al., Dev Cell 2013*
• IRef Biogrid Interaction: EGFR — HGS (physical association, affinity chromatography technology) Ali et al., Curr Biol 2013*
• IRef Biogrid Interaction: EGFR — HGS (physical association, affinity chromatography technology) Umebayashi et al., Mol Biol Cell 2008
• IRef Dip Interaction: EGFR — HGS (physical association, anti bait coimmunoprecipitation) Vivanco et al., Proc Natl Acad Sci U S A 2010*
• IRef Hprd Interaction: EGFR — HGS (in vitro) Urbé et al., J Cell Sci 2003*

Text-mined interactions from Literome

Chin et al., J Biol Chem 2001 : Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor ... Overexpression of Hrs or its SNX1 binding domain inhibits ligand induced degradation of EGFR , but does not affect either constitutive or ligand induced receptor mediated endocytosis
Katz et al., Traffic 2002 : Ligand independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs , an adaptor whose ubiquitin interacting motif targets ubiquitylation by Nedd4
Kanazawa et al., Biochem Biophys Res Commun 2003 : We also demonstrate that ligand mediated epidermal growth factor receptor (EGFR) degradation is partially but not completely impaired in both Hrs ( -/- ) and STAM1 ( -/- ) STAM2 ( -/- ) mouse embryonic fibroblasts
Scoles et al., Biochem Biophys Res Commun 2005 (Neurilemmoma) : This study is the first to show that HRS can reduce the abundance of total and active EGFR and may reflect cell type-specific HRS function
Meijer et al., Cell Signal 2012 : EGF stimulation of the EGFR resulted in efficient Hrs tyrosine phosphorylation and deubiquitination by the K63-polyubiquitin chain-specific deubiquitinating enzyme AMSH