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CAV1 — IGF1
Text-mined interactions from Literome
Maggi et al., Biochem Biophys Res Commun 2002
:
IGF-I induces
caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts
Podar et al., J Biol Chem 2003
(Multiple Myeloma) :
Interleukin-6 and
insulin-like growth factor-I , growth and survival factors in multiple myeloma,
induce caveolin-1 phosphorylation, which is abrogated by pre-treatment with beta-cyclodextrin
Lin et al., Invest Ophthalmol Vis Sci 2003
:
Phorbol ester ( TPA ) and insulin-like growth factor
(IGF)-1 recruited PKCgamma into Cav-1 containing lipid rafts and
stimulated the interactions of PKCgamma with
Cav-1 and Cx43 ... Activation of PKCgamma by TPA or
IGF-1 stimulated the interaction of PKCgamma with
Cav-1 and Cx43 in lipid rafts, causing Cx43, Cav-1, and PKCgamma to redistribute within the lipid rafts, and this resulted in a decrease in gap junction plaques
Panetta et al., Biochem Biophys Res Commun 2004
:
IGF-I regulates
caveolin 1 and IRS1 interaction in caveolae
Repetto et al., Biochem Biophys Res Commun 2005
:
Since Insulin and IGF-I phosphorylate and activate eNOS, we investigated the
role of
caveolin-1 in Insulin and
IGF-I stimulated eNOS activity ... These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the
role of
caveolin-1 in the eNOS activation by Insulin and
IGF-I
Glait et al., Exp Cell Res 2006
(Breast Neoplasms) :
In addition, we demonstrated that transcriptional
activation of the
IGF-IR gene by
Cav-1 requires an intact p53 signaling pathway, since Cav-1 was unable to elevate IGF-IR levels in p53-null cells
Salani et al., Endocrinology 2008
:
To determine the
role of
Cav-1 in
IGF-IR signaling, we transfected H9C2 cells with small interfering RNA specific for Cav-1-siRNA ... These results demonstrate that : 1 ) Cav-1 down-regulation negatively affects IGF-IR tyrosine phosphorylation ; 2 ) this effect causes a reduced activation of insulin receptor substrate-1, Shc, and Akt ; and 3 )
Cav-1 is
involved in
IGF-IR antiapoptotic signaling after serum deprivation
Matthews et al., Endocrinology 2008
:
Modulation of
caveolin-1 expression can affect signalling through the phosphatidylinositol 3-kinase/Akt pathway and cellular proliferation in
response to
insulin-like growth factor I ... Interestingly,
IGF-I induced proliferation was similar in MF ( -/- ) and MF ( +/+ ) cells, whereas
caveolin-1 knockdown promoted a hyperproliferative response to IGF-I [ pkDCav3T3L1 ( 80 ) 12.4+/-0.4-fold ; pkDShuffle3T3L1 4.3+/-0.2-fold induction ; P < 0.01 ] ... Interestingly,
IGF-I induced proliferation was similar in MF ( -/- ) and MF ( +/+ ) cells, whereas
caveolin-1 knockdown promoted a hyperproliferative response to IGF-I [ pkDCav3T3L1 ( 80 ) 12.4+/-0.4-fold ; pkDShuffle3T3L1 4.3+/-0.2-fold induction ; P < 0.01 ]