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APC — KRAS

Text-mined interactions from Literome

Babbar et al., Biochem Soc Trans 2003 (Intestinal Neoplasms) : Inactivation of the APC tumour-suppressor gene, and the activation of K-ras , have a combined effect on increasing tissue polyamine contents due to increased synthesis and decreased catabolism of the polyamines
Phelps et al., Cell 2009 (Adenoma...) : APC mutation induced intestinal differentiation defects instead depend on the transcriptional corepressor C-terminal binding protein-1 (CtBP1), whereas proliferation defects and nuclear accumulation of beta-catenin require the additional activation of KRAS
Sevignani et al., J Clin Invest 1998 (Cell Transformation, Neoplastic...) : Distinct genetic abnormalities ( loss-of-function mutations of APC and p53 and oncogenic activation of Ki-ras ) are associated with specific stages of the sporadic, most common types of colorectal tumors