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IL12A — IL17A
Text-mined interactions from Literome
Aggarwal et al., J Biol Chem 2003
:
In contrast to IL-23,
IL-12 had only marginal effects on
IL-17 production
Hoeve et al., Eur J Immunol 2006
(Arthritis...) :
Divergent
effects of
IL-12 and IL-23 on the production of
IL-17 by human T cells ... In contrast,
IL-12 mediated specific inhibition of
IL-17 production
Wheeler et al., Immunology 2006
(Encephalomyelitis, Autoimmune, Experimental) :
There was greater expression of
IL-12/23p40 by antigen presenting cells in these mice, and in vitro, TNFR1-/- antigen presenting cells
induced greater secretion of IFN-gamma but not
interleukin (IL)-17 when cultured with primed T cells than did WT antigen presenting cells
Nakae et al., J Leukoc Biol 2007
:
We found that IL-23 or
IL-17 can suppress Th1 cell differentiation in the
presence of exogenous
IL-12 in vitro
Sheibanie et al., J Immunol 2007
(Colitis...) :
We assessed the effects of PGE ( 2 ) on IL-12, IL-27, and IL-23 and found that PGE ( 2 ) promotes IL-23,
inhibits IL-12 and IL-27 expression and release from stimulated DCs, and subsequently induces
IL-17 production in activated T cells
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced IFN-gamma,
IL-17A , tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Romagnani et al., Arthritis Res Ther 2008
(Autoimmune Diseases) :
Moreover, the presence in the circulation and in various tissues of Th cells that can produce both
IL-17 and interferon-gamma, as well as the flexibility of human Th17 clones to produce interferon-gamma in addition to IL-17 in
response to
IL-12 , suggests that there may be a developmental relationship between Th17 and Th1 cells, at least in humans
Takedatsu et al., Gastroenterology 2008
(Chronic Disease...) :
Furthermore, IFN-gamma and
IL-17 production from CD4 ( + ) T cells,
induced by
IL-12 and IL-23 respectively, was enhanced synergistically by combination with TL1A
Mo et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental...) :
Signal transducer and activator of transcription 4 ( Stat4 ) is a transcription factor
activated by
IL-12 and IL-23, two cytokines known to play important roles in the pathogenesis of EAE by inducing T cells to secrete IFN-gamma and
IL-17 , respectively
Lemos et al., Proc Natl Acad Sci U S A 2009
(Arthritis, Rheumatoid...) :
Our results suggest that prostaglandin plays an important role in IL-23 induced neutrophil migration in arthritis by enhancing
IL-17 synthesis and by
inhibiting IL-12 and IFNgamma production
Rovedatti et al., Gut 2009
(Colitis, Ulcerative...) :
IL23 and IL1beta plus IL6 had no effect on IBD LPMC production of
IL17 ; however,
IL12 markedly
increased IFNgamma production and decreased IL17 production ... Our findings support a
role for
IL12 , TGFbeta and IL21 in modulating
IL17/IFNgamma production in IBD
Lin et al., Immunity 2009
(Tularemia) :
Furthermore, we show that
IL-17A also
induced IL-12 and interferon-gamma production in macrophages and mediated bacterial killing
Clarke et al., MAbs 2010
:
Antibodies with this unique mechanism of inhibition are potent inhibitors of
IL-12 induced IFN-? production and IL-23
induced IL-17 production in vitro, and in an in vivo model of psoriasis, treatment with a humanized variant of this antibody, h6F6, reduced the inflammatory response, resulting in decreased epidermal hyperplasia
Feng et al., J Immunol 2011
(Colitis) :
Th17 cells induce colitis and promote Th1 cell responses through
IL-17 induction of innate
IL-12 and IL-23 production ...
IL-17 promoted dendritic cell production of
IL-12 and IL-23 ... Collectively, these data indicate that Th17 cells convert to Th1 cells through
IL-17 induction of mucosal innate
IL-12 and IL-23 production
Gopal et al., Eur J Immunol 2012
(Disease Models, Animal...) :
The ability of
IL-17 to downregulate IL-10 and
induce IL-12 production allows the generation of subsequent Th1-cell responses
Awoniyi et al., PloS one 2012
(Salmonella Infections) :
IL-12 and IL-23
regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-?,
IL-17 , and IL-22
Zhong et al., Blood 2012
(Purpura, Thrombocytopenic, Idiopathic) :
Th-1 polarizing cytokine
IL-12 , secreted after direct contact of patient T-cell and CD16 ( + ) monocytes, was responsible for the inhibitory
effect on Treg and
IL-17 ( + ) CD4 ( + ) cell proliferation
Rasouli et al., Cytokine 2013
(Brucellosis...) :
It is also clarified that
IL-17 is
required for the induction of IFN-? and
IL-12 in macrophages and dendritic cells