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RHOA — SERPINE1

Text-mined interactions from Literome

Sakamoto et al., Atherosclerosis 2007 (Calcium Signaling) : RhoA dependent PAI-1 gene expression induced in endothelial cells by monocyte adhesion mediates geranylgeranyl transferase I and Ca2+ signaling ... Inhibition of RhoA by C3 exoenzyme or by adenovirus mediated expression of N19RhoA, as well as by pravastatin, prevented the upregulation of PAI-1 induced by monocyte adhesion ... The present study shows that GGTase I plays a role in the RhoA activation in endothelial cells induced by monocyte adhesion and that GGTase I-mediated Ca ( 2+ ) signaling may contribute to RhoA dependent PAI-1 gene expression
Samarakoon et al., J Mol Cell Cardiol 2008 : Transient transfection of a dominant negative RhoA ( DN-RhoA ) expression construct or pretreatment of VSMC with C3 transferase ( a Rho inhibitor ) or Y-27632 ( an inhibitor of p160ROCK, a downstream effector of Rho ) also dramatically attenuated the TGF-beta1 initiated PAI-1 inductive response
Ando et al., J Atheroscler Thromb 2011 : Inhibition of RhoA attenuated thrombin triggered [ Ca ( 2+ ) ] ( i ) increase and TF and PAI-1 expression in HAECs, whereas thrombin triggered ROS generation and TF and PAI-1 expression were blocked by inhibition of Rac1