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APC — IL4
Text-mined interactions from Literome
Richards et al., Eur J Immunol 2000
:
The additional presence of
antigen presenting cells (APC) in the priming culture maintains IL-10 levels, but
inhibits IL-4 and IL-5 production
Zhong et al., Anesthesiology 2004
(Myocardial Infarction...) :
APC with sevoflurane attenuated NF-kappaB activation and
reduced the expression of tumor necrosis factor alpha,
interleukin 1, intercellular adhesion molecule 1, and inducible nitric oxide synthase
Mehrotra et al., Immunology 2004
(Melanoma) :
Among the various microenvironmental factors,
interleukin-10 (IL-10) exhibits a potent immunosuppressive
effect on
antigen presenting cells (APC)
Chen et al., J Immunol 1992
:
Thus, our study indicates that CsA potentiation of Ag-specific IgE response is due to cumulative action of CsA on two independent pathways : first, CsA differentially
modulates IL-4 and IFN-gamma levels during the early phase of cognate Th2/B cell interaction ; and second, CsA directly affects
APC and IgE isotype-specific amplifying cellular components without apparently affecting the secretory levels of IL-4 and IFN-gamma
Mannie et al., J Immunol 2007
(Encephalomyelitis, Autoimmune, Experimental) :
IL4NAg was approximately 100-fold more active than NAg alone in the
presence of splenic
APC
Vogt et al., Microbes Infect 2008
(Chagas Disease) :
Lymph node TCRBV9+ T cells secreted IFN-gamma and IL-10, but not
IL-4 , upon stimulation with TcAg in the
presence of
APC
Blanchfield et al., J Leukoc Biol 2010
(Disease Progression...) :
GMCSF-NAg and MCSF-NAg targeted NAg to DC and macrophages ; conversely,
IL4-NAg and IL2-NAg fusion proteins, respectively, induced an 1000-fold enhancement in NAg reactivity in the
presence of B cell and T cell
APC
Piuvezam et al., J Immunol 1993
:
T cell lines generated against Tct proliferated in response to parasite lysate only in the
presence of autologous
APC and produced IL-2, IL-6, and IFN-gamma but not
IL-4 in response to PMA plus ionomycin
Li et al., Int Immunol 1996
:
CT-pretreated
APC also
enhanced IL-4 production from anti-CD3 mAb stimulated T cells, indicating that CT was providing a co-stimulatory signal