Gene interactions and pathways from curated databases and text-mining

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CEBPD — IL1A

Text-mined interactions from Literome

Désilets et al., Biochem Biophys Res Commun 2000 : Gel shift and supershift assays showed a strong decrease in the IL-1 induced C/EBPbeta and C/EBPdelta containing complexes binding to the HaptoA C/EBP DNA binding site of the haptoglobin promoter, by NaBu and TSA
Svotelis et al., Biochem Biophys Res Commun 2005 : C/EBP delta regulates several inflammatory response genes, such as haptoglobin, in the rat intestinal epithelial cell line IEC-6 in response to IL-1
Miyoshi et al., Clin Exp Nephrol 2007 (Glomerulonephritis) : In the in vitro study, IL-1beta increased C/EBP-delta mRNA levels in NS siRNA transfected MCs ( 7.3-fold ), but no increase was evident in C/EBP-delta siRNA transfected MCs
Ali et al., Int J Biochem Cell Biol 2010 : The IL-1 mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) ( curcumin and SP600125 ), casein kinase 2 ( CK2 ) ( apigenin ) and nuclear factor-kappaB (NF-kappaB) ( NF-kappaB activation inhibitor ) ... RNA interference assays showed significant attenuation of the IL-1 induced expression of C/EBPdelta following knockdown of the p50 and p65 subunits of NF-kappaB ... Taken together, these results suggest a potentially crucial role for NF-kappaB in the IL-1 induced expression of C/EBPdelta , and thereby downstream APP genes regulated by this transcription factor