Gene interactions and pathways from curated databases and text-mining

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IL1A — IL1R1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Böl et al., Biofactors 1999 (Thymoma...) : Stimulation of the Interleukin-1 receptor type I (IL-1-RI) with IL-1 activates an associated serine/threonine kinase, IRAK, which phosphorylates downstream targets, resulting in NFkappaB activation
Ando et al., Mol Cell Endocrinol 1999 : The upregulation by IL-1 of IL-1beta, IL-1R and IL-1RA transcripts was similarly inhibited by indomethacin
Neumann et al., J Immunol 2000 : IL-1 signaling is mediated by the type I IL-1R ( IL-1RI )
Sugawara et al., Microbiol Immunol 2001 (Tuberculosis, Pulmonary) : In order to clarify the role of IL-1 receptor type 1 (IL-1 R1) in IL-1 R1 , knockout ( KO ) mice were infected with either Mycobacterium tuberculosis H37Rv or Kurono strain by the respiratory route, and their ability to control mycobacterial growth, pulmonary granuloma formation, and cytokine mRNA expression was investigated
Bahi et al., Hum Mol Genet 2003 (Calcium Signaling...) : In order to begin to elucidate the function of this IL-1/Toll receptor-like protein, we have assessed the effect of recombinant IL1RAPL on the binding affinity of type I IL-1R for its ligands IL-1alpha and beta and searched for proteins interacting with the specific carboxy terminus domain of IL1RAPL
Takii et al., Eur J Immunol 1992 : The regulation of interleukin-1 receptor (IL-1R) mRNA expression by IL-1 in a human lung fibroblast cell line ( TIG-1 ) was investigated ... These results indicate that IL-1 does not directly stimulate expression of IL-1R mRNA or cell surface IL-1R , but only indirectly by stimulation of endogenous PGE2
Liberman et al., Eur J Immunol 1992 : Our binding and functional studies strongly support the hypothesis that high-affinity IL-1R on the one hand, and low-affinity ones on the other hand, are involved in the response to IL-1 + IL-2 of newborn and day 17.5 fetal thymocytes, respectively
Huang et al., Nat Immunol 2004 : MEKK3 forms a complex with TRAF6 in response to IL-1 and lipopolysaccharide (LPS) but not CpG, and is required for IL-1R- and TLR4 induced IL-6 production
Hagiwara et al., Cytokine 2005 : IL1R1 contributes to IL-1 signaling, whereas the IL1R2 has no signaling property and acts as a decoy for IL-1
Dubois et al., Blood 1991 : Injection of mice with IL-1 results in a marked upregulation of IL-1R on light-density BM cells as on a subpopulation enriched for myeloid precursors ... Pretreatment of mice with anti-type I IL-1R antibody ( 35F5 ), which has been shown to prevent the radioprotective effect of IL-1, also blocked IL-1 induced IL-1R expression on BM cells ... This antibody did not directly bind and block IL-1 binding to the type II IL-1R expressed on hematopoietic cells, suggesting that IL-1R upregulation by IL-1 is indirect
Ching et al., J Neurosci 2007 (Fever) : These results show that the effects of intravenous and intracerebroventricular IL-1 are mediated by endothelial IL-1R1 , whereas the effects of intraperitoneal IL-1 are partially dependent on endothelial IL-1R1
McIntyre et al., J Exp Med 1991 (Acute-Phase Reaction...) : Thus, IL-1ra and 35F5 competitively inhibit the binding of IL-1 to the IL-1R on certain cell types
Bird et al., Biochem Biophys Res Commun 1991 : In contrast to a previous report, little or no IL1R phosphorylation occurred in response to IL1
Turnquist et al., J Immunol 2008 : Interestingly, IL-1beta production promotes overexpression of the transmembrane form of the IL-1R family member, IL-1R-like 1, also know as ST2 on RAPA conditioned DC ( RAPA-DC )
Thompson et al., J Immunol 2012 : We vaccinated IL-1R1 bone marrow ( BM ) chimeric mice to determine whether IL-1R1 expression on stromal cells or hematopoietic cells was sufficient for the maximal adjuvant activity of nasally delivered IL-1a as determined by the acute induction of cytokine responses and induction of Bacillus anthracis lethal factor ( LF ) -specific adaptive immunity
Pang et al., Journal of neuroinflammation 2012 (MAP Kinase Signaling System) : Telmisartan reduced the IL-1ß induced increase in IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression, NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide induced COX-2 gene expression ... The effect of telmisartan on IL-1ß stimulated COX-2 and IL-1R1 mRNA expression and ROS production was replicated in primary rat cortical neurons
Baluk et al., Am J Pathol 2013 (Hypertrophy...) : Further studies examined how IL1R1 receptor activation by IL-1ß induced lymphangiogenesis
Chiao et al., Clin Sci (Lond) 2013 : LPS induced plasma levels of IL-1ß , TNFa ( tumour necrosis factor a ), IL-10, vascular eNOS ( endothelial NOS ) and COX2 ( cyclo-oxygenase 2 ) protein expression, as determined by ELISA and Western blot, observed in WT mice were inhibited by IL1ra and in P2X7KO mice
Negoro et al., Scientific reports 2013 (Disease Models, Animal...) : IL-1ß also increased IL-1ß, IL-1R-1 , PANX1 and CASP1 expression
Akahoshi et al., J Clin Invest 1988 : These data suggest that the later IL 1-induced up-regulation of IL 1R is mediated by IL 1 stimulation of endogenous prostaglandin production
Loppnow et al., Prog Clin Biol Res 1994 : IL1Ra reduced the activation of EC and SMC by recombinant IL1 , as well as the activation of SMC with vascular cell derived membrane IL1 in coculture experiments
Tan et al., J Immunol 1995 : We observed that IL-1 alpha could induce chemotaxis both in overnight cultured and anti-CD3 mAb activated T lymphocytes and that overnight culture and anti-CD3 activation increase the number of IL-1R on T lymphocytes
Takii et al., Lymphokine Cytokine Res 1994 : In this study, the effect of IL-1 on IL-1R mRNA expression was investigated in the absence of PGE2 synthesis ... These results indicate that IL-1 regulates IL-1R mRNA expression in both a positive and negative manner, and that the negative effect represents a negative feedback mechanism
Colotta et al., Science 1993 : These results, together with the effect of antibodies to IL-1R on IL-1 induced production of cytokines in monocytes, indicate that IL-1 acts on myelomonocytic cells through IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1
Lacey et al., J Clin Invest 1993 : IL-1 induces ( IL-1 ED50, 0.1 pM ) IL-6 production through the type 1 IL-1R as 35F5 antibodies block IL-1 stimulated IL-6 production
Bruserud et al., Eur J Haematol 1996 (Acute-Phase Reaction...) : IL1 alpha and IL1 beta caused a similar increase in AML blast release of IL1RA , and addition of anti-IL1 antibodies decreased IL1RA release
Takii et al., J Interferon Cytokine Res 1995 : We previously reported that IL-1 upregulates transcription and cell surface molecules of type I IL-1R in TIG-1 cells through induction of prostaglandin ( PG ) E2 and cAMP accumulation
Kanda-Nakamura et al., J Periodontol 1996 (Gingivitis...) : We investigated the expression of interleukin-1 receptors (IL-1R) on the surfaces of cultured gingival fibroblasts derived from healthy and inflamed gingiva and the effects of IL-1 alpha and IL-1 beta and prostaglandin E2 ( PGE2 ) on IL-1R expression
Yoon et al., J Immunol 1998 : The IL-1R accessory protein (IL-1RAcP) plays a role in IL-1R signaling by forming a complex with IL-1RI bound to the IL-1 ligand
Born et al., J Biol Chem 1998 : We propose that although IL-1R-rp1 binds the cytokine, IL-1R-rp1 and AcPL proteins are both required for IL-18 signaling, analogous to the requirement for both IL-1R and IL-1RAcP in IL-1 mediated responses