◀ Back to IL1A
IL1A — IL1R1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL1R1
→
Complex of IL1A-IL1R1
(increases, IL1A/IL1R1 Activity)
Daffada et al., FEBS Lett 1999*
Evidence: We found that IL-1alpha, IL-1beta and IL-6 increased both metallothionein-1 (MT-1) and metallothionein-2 (MT-2) mRNA in HepG2 cells.
-
OpenBEL Selventa BEL large corpus:
IL1R1
→
IL1A
(directlyIncreases, IL1A Activity)
Evidence: Furthermore, IL-18R at least partly shares the signal transducing system with IL-1R. Thus, the IL-18-IL-18R system has a striking similarity to the IL-1-IL-1R system. From entrez gene summary of IL1R1: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induce...
-
OpenBEL Selventa BEL large corpus:
IL1R1
→
IL1A
(directlyIncreases, IL1A Activity)
Evidence: IL-1RI activation is induced by IL-1? and IL-1? binding,
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IL-1-alpha (IL1A)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
IL-1-alpha (IL1A)
→
IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
TOLLIP
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-alpha (IL1A)
→
IL-1R (IL1R1)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-alpha (IL1A)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
MYD88
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1RAcP (IL1RAP)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1RA (IL1RN)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, inhibits)
-
BioCarta signal transduction through il1r:
IL-1R (IL1R1)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
TRAF6
(modification, activates)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
TAB1/TAK1 complex (MAP3K7IP1-MAP3K7)
(modification, activates)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
-
KEGG Apoptosis:
IL1A/IL1B
→
IL1R1/IL1RAP
(protein-protein, activation)
-
KEGG Osteoclast differentiation:
IL1A/IL1B
→
IL1R1
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
IL1A/IL1B
→
IL1R1/IL1R2
(protein-protein, activation)
-
KEGG Cytokine-cytokine receptor interaction:
IL1A
→
Complex of IL1R1-IL1RAP
(protein-protein, activation)
-
NCI Pathway Database IL1-mediated signaling events:
IL1RAP (IL1RAP)
→
IL1 alpha/IL1R1/IL1RAP complex (IL1A-IL1R1-IL1RAP)
(modification, collaborate)
Sims et al., Proc Natl Acad Sci U S A 1989*, Greenfeder et al., J Biol Chem 1995*
Evidence: physical interaction, other species
-
NCI Pathway Database IL1-mediated signaling events:
IL1R1 (IL1R1)
→
IL1 alpha (IL1A)
(modification, collaborate)
Sims et al., Proc Natl Acad Sci U S A 1989*, Greenfeder et al., J Biol Chem 1995*
Evidence: physical interaction, other species
-
NCI Pathway Database IL1-mediated signaling events:
IL1R1 (IL1R1)
→
IL1 alpha/IL1R1/IL1RAP complex (IL1A-IL1R1-IL1RAP)
(modification, collaborate)
Sims et al., Proc Natl Acad Sci U S A 1989*, Greenfeder et al., J Biol Chem 1995*
Evidence: physical interaction, other species
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha (IL1A)
→
IL1 alpha/IL1R1/IL1RAP complex (IL1A-IL1R1-IL1RAP)
(modification, collaborate)
Sims et al., Proc Natl Acad Sci U S A 1989*, Greenfeder et al., J Biol Chem 1995*
Evidence: physical interaction, other species
-
NCI Pathway Database IL1-mediated signaling events:
MYD88 (MYD88)
→
IL1 alpha/IL1R1/IL1RAP complex (IL1A-IL1R1-IL1RAP)
(modification, collaborate)
Medzhitov et al., Mol Cell 1998*
Evidence: mutant phenotype
-
NCI Pathway Database IL1-mediated signaling events:
MYD88 (MYD88)
→
IL1 alpha/IL1R1/IL1RAP/MYD88 complex (IL1A-IL1R1-IL1RAP-MYD88)
(modification, collaborate)
Medzhitov et al., Mol Cell 1998*
Evidence: mutant phenotype
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP complex (IL1A-IL1R1-IL1RAP)
→
IL1 alpha/IL1R1/IL1RAP/MYD88 complex (IL1A-IL1R1-IL1RAP-MYD88)
(modification, collaborate)
Medzhitov et al., Mol Cell 1998*
Evidence: mutant phenotype
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IRAK4 (IRAK4)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IL1 alpha/IL1R1/IL1RAP/MYD88 complex (IL1A-IL1R1-IL1RAP-MYD88)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IL1-mediated signaling events:
IRAK4 (IRAK4)
→
IL1 alpha/IL1R1/IL1RAP/MYD88 complex (IL1A-IL1R1-IL1RAP-MYD88)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IRAK/TOLLIP complex (IRAK1-TOLLIP)
(modification, collaborate)
Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
-
NCI Pathway Database IL1-mediated signaling events:
IRAK/TOLLIP complex (IRAK1-TOLLIP)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
-
Reactome Reaction:
IL1A
→
IL1R1
(reaction)
Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Sims et al., Proc Natl Acad Sci U S A 1993*
-
Reactome Reaction:
IL1A
→
IL1R1
(direct_complex)
Sims et al., Proc Natl Acad Sci U S A 1993*
-
WikiPathways Hypertrophy Model:
IL1R1
→
IL1A
(Receptor)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
IL1A
→
IL1R1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Böl et al., Biofactors 1999
(Thymoma...) :
Stimulation of the
Interleukin-1 receptor type I (IL-1-RI) with
IL-1 activates an associated serine/threonine kinase, IRAK, which phosphorylates downstream targets, resulting in NFkappaB activation
Ando et al., Mol Cell Endocrinol 1999
:
The
upregulation by
IL-1 of IL-1beta,
IL-1R and IL-1RA transcripts was similarly inhibited by indomethacin
Neumann et al., J Immunol 2000
:
IL-1 signaling is
mediated by the type I
IL-1R ( IL-1RI )
Sugawara et al., Microbiol Immunol 2001
(Tuberculosis, Pulmonary) :
In order to clarify the
role of
IL-1 receptor type 1 (IL-1 R1) in
IL-1 R1 , knockout ( KO ) mice were infected with either Mycobacterium tuberculosis H37Rv or Kurono strain by the respiratory route, and their ability to control mycobacterial growth, pulmonary granuloma formation, and cytokine mRNA expression was investigated
Bahi et al., Hum Mol Genet 2003
(Calcium Signaling...) :
In order to begin to elucidate the function of this IL-1/Toll receptor-like protein, we have assessed the
effect of recombinant
IL1RAPL on the binding affinity of type I
IL-1R for its ligands IL-1alpha and beta and searched for proteins interacting with the specific carboxy terminus domain of IL1RAPL
Takii et al., Eur J Immunol 1992
:
The
regulation of
interleukin-1 receptor (IL-1R) mRNA expression by
IL-1 in a human lung fibroblast cell line ( TIG-1 ) was investigated ... These results indicate that
IL-1 does not directly
stimulate expression of IL-1R mRNA or cell surface
IL-1R , but only indirectly by stimulation of endogenous PGE2
Liberman et al., Eur J Immunol 1992
:
Our binding and functional studies strongly support the hypothesis that high-affinity
IL-1R on the one hand, and low-affinity ones on the other hand, are involved in the
response to
IL-1 + IL-2 of newborn and day 17.5 fetal thymocytes, respectively
Huang et al., Nat Immunol 2004
:
MEKK3 forms a complex with TRAF6 in
response to
IL-1 and lipopolysaccharide (LPS) but not CpG, and is required for
IL-1R- and TLR4 induced IL-6 production
Hagiwara et al., Cytokine 2005
:
IL1R1 contributes to
IL-1 signaling, whereas the IL1R2 has no signaling property and acts as a decoy for IL-1
Dubois et al., Blood 1991
:
Injection of mice with
IL-1 results in a marked upregulation of
IL-1R on light-density BM cells as on a subpopulation enriched for myeloid precursors ... Pretreatment of mice with anti-type I IL-1R antibody ( 35F5 ), which has been shown to prevent the radioprotective effect of IL-1, also blocked
IL-1 induced
IL-1R expression on BM cells ... This antibody did not directly bind and block IL-1 binding to the type II IL-1R expressed on hematopoietic cells, suggesting that
IL-1R upregulation by
IL-1 is indirect
Ching et al., J Neurosci 2007
(Fever) :
These results show that the effects of intravenous and intracerebroventricular
IL-1 are
mediated by endothelial
IL-1R1 , whereas the effects of intraperitoneal IL-1 are partially dependent on endothelial IL-1R1
McIntyre et al., J Exp Med 1991
(Acute-Phase Reaction...) :
Thus,
IL-1ra and 35F5 competitively
inhibit the binding of IL-1 to the
IL-1R on certain cell types
Bird et al., Biochem Biophys Res Commun 1991
:
In contrast to a previous report, little or no
IL1R phosphorylation occurred in
response to
IL1
Turnquist et al., J Immunol 2008
:
Interestingly,
IL-1beta production
promotes overexpression of the transmembrane form of the IL-1R family member,
IL-1R-like 1, also know as ST2 on RAPA conditioned DC ( RAPA-DC )
Thompson et al., J Immunol 2012
:
We vaccinated IL-1R1 bone marrow ( BM ) chimeric mice to determine whether
IL-1R1 expression on stromal cells or hematopoietic cells was
sufficient for the maximal adjuvant activity of nasally delivered
IL-1a as determined by the acute induction of cytokine responses and induction of Bacillus anthracis lethal factor ( LF ) -specific adaptive immunity
Pang et al., Journal of neuroinflammation 2012
(MAP Kinase Signaling System) :
Telmisartan reduced the
IL-1ß induced increase in
IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression, NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide induced COX-2 gene expression ... The effect of telmisartan on
IL-1ß stimulated COX-2 and
IL-1R1 mRNA expression and ROS production was replicated in primary rat cortical neurons
Baluk et al., Am J Pathol 2013
(Hypertrophy...) :
Further studies examined how
IL1R1 receptor
activation by
IL-1ß induced lymphangiogenesis
Chiao et al., Clin Sci (Lond) 2013
:
LPS induced plasma levels of
IL-1ß , TNFa ( tumour necrosis factor a ), IL-10, vascular eNOS ( endothelial NOS ) and COX2 ( cyclo-oxygenase 2 ) protein expression, as determined by ELISA and Western blot, observed in WT mice were
inhibited by
IL1ra and in P2X7KO mice
Negoro et al., Scientific reports 2013
(Disease Models, Animal...) :
IL-1ß also
increased IL-1ß,
IL-1R-1 , PANX1 and CASP1 expression
Akahoshi et al., J Clin Invest 1988
:
These data suggest that the later IL 1-induced up-regulation of
IL 1R is
mediated by
IL 1 stimulation of endogenous prostaglandin production
Loppnow et al., Prog Clin Biol Res 1994
:
IL1Ra reduced the activation of EC and SMC by recombinant
IL1 , as well as the activation of SMC with vascular cell derived membrane IL1 in coculture experiments
Tan et al., J Immunol 1995
:
We observed that
IL-1 alpha could induce chemotaxis both in overnight cultured and anti-CD3 mAb activated T lymphocytes and that overnight culture and anti-CD3 activation
increase the number of
IL-1R on T lymphocytes
Takii et al., Lymphokine Cytokine Res 1994
:
In this study, the
effect of
IL-1 on
IL-1R mRNA expression was investigated in the absence of PGE2 synthesis ... These results indicate that
IL-1 regulates
IL-1R mRNA expression in both a positive and negative manner, and that the negative effect represents a negative feedback mechanism
Colotta et al., Science 1993
:
These results, together with the effect of antibodies to IL-1R on IL-1 induced production of cytokines in monocytes, indicate that
IL-1 acts on myelomonocytic cells through
IL-1R I and that IL-1R II inhibits IL-1 activity by acting as a decoy target for IL-1
Lacey et al., J Clin Invest 1993
:
IL-1 induces ( IL-1 ED50, 0.1 pM ) IL-6 production through the type 1
IL-1R as 35F5 antibodies block IL-1 stimulated IL-6 production
Bruserud et al., Eur J Haematol 1996
(Acute-Phase Reaction...) :
IL1 alpha and IL1 beta
caused a similar increase in AML blast release of
IL1RA , and addition of anti-IL1 antibodies decreased IL1RA release
Takii et al., J Interferon Cytokine Res 1995
:
We previously reported that
IL-1 upregulates transcription and cell surface molecules of type I
IL-1R in TIG-1 cells through induction of prostaglandin ( PG ) E2 and cAMP accumulation
Kanda-Nakamura et al., J Periodontol 1996
(Gingivitis...) :
We investigated the expression of interleukin-1 receptors (IL-1R) on the surfaces of cultured gingival fibroblasts derived from healthy and inflamed gingiva and the
effects of
IL-1 alpha and IL-1 beta and prostaglandin E2 ( PGE2 ) on
IL-1R expression
Yoon et al., J Immunol 1998
:
The IL-1R accessory protein (IL-1RAcP)
plays a role in
IL-1R signaling by forming a complex with
IL-1RI bound to the IL-1 ligand
Born et al., J Biol Chem 1998
:
We propose that although IL-1R-rp1 binds the cytokine, IL-1R-rp1 and AcPL proteins are both required for IL-18 signaling, analogous to the requirement for both
IL-1R and IL-1RAcP in
IL-1 mediated responses