Gene interactions and pathways from curated databases and text-mining

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CSF2 — SLPI

Text-mined interactions from Literome

Baranova et al., Int J Hematol 1999 (Neutropenia...) : As described in studies on the effect of rhG-CSF on ALP activity in healthy individuals, ALP activity was higher in SCN patients already on treatment with rhG-CSF
Yamaoka et al., Rinsho Byori 1992 (Leukemia, Promyelocytic, Acute) : rhG-CSF induced a small but significant increase of NBT reducing ability and ALP activity of the HL-60 cells ... Among various inducers of cell differentiation, 1,25 ( OH ) 2D3 and dimethylsulfoxide ( DMSO ) caused the increase of the NBT reducing ability and the suppression of ALP activity induced by rhG-CSF , while RA enhanced both of them
Taoka et al., Leuk Res 1993 (Leukemia, Promyelocytic, Acute) : Recombinant human granulocyte colony stimulating factor ( rhG-CSF ) not only enhanced the growth of HL-60 cells, but also significantly increased NBT reducing ability and alkaline phosphatase (ALP) activity of the cells, which were enhanced by the treatment with retinoic acid ( RA ) ... This study suggests that RA and rhG-CSF are the potent inducers of ALP activity of HL-60 cells and protein kinase C is supposed to have a role in this induction of ALP
Tsuruta et al., Br J Haematol 1996 (Leukemia, Myeloid...) : With stimulation, the ALP mRNA expression in both fractions was strongly enhanced by G-CSF, but the expression was inhibited by GM-CSF and/or IL-3