Yim et al., J Biol Chem 2003
(Anoxia) :
Our results indicate that hypoxia but not insulin stabilizes HIF-1alpha protein levels, whereas both insulin- and hypoxia induced gene expression require the presence of the Arnt protein Gunton et al., Cell 2005
(Diabetes Mellitus, Type 2...) :
Reducing ARNT levels in Min6 cells with small interfering RNA ( siRNA ) resulted in markedly impaired glucose stimulated insulin release and changes in gene expression similar to those in human type 2 islets
Kim et al., Biochem Biophys Res Commun 2009
(Insulinoma) :
Recently, it was reported that ARNT is essential for adequate insulin secretion in response to glucose input and that its expression is downregulated in the pancreatic islets of diabetic patients ... In the present study, the authors addressed the mechanism by which ARNT regulates insulin secretion in the INS-1 insulinoma cell line
Zelzer et al., EMBO J 1998
:
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT ... Finally, insulin-like growth factor-I (IGF-I) also induced the HIF-1alpha/ARNT transcription complex