◀ Back to INS

CYP3A — INS

Text-mined interactions from Literome

Woodcroft et al., J Pharmacol Exp Ther 1999 : Insulin differentially affects xenobiotic enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A , and CYP4A expression in primary cultured rat hepatocytes ... In the present study, we examined the effects of insulin on pyridine-, phenobarbital-, and ciprofibrate mediated expression of CYP2E1, CYP2B, CYP3A , and CYP4A in primary cultured rat hepatocytes ... To examine whether insulin effects on xenobiotic mediated CYP2E1 expression were selective, insulin effects on xenobiotic mediated expression of transcriptionally regulated CYP2B, CYP3A , and CYP4A were examined ... Omitting insulin from the medium resulted in a 50 % decrease in CYP3A mRNA levels in response to phenobarbital treatment and a 30 % decrease in CYP4A mRNA levels in response to ciprofibrate treatment, relative to the level obtained in response to these treatments in the presence of 1 microM insulin ... The results of this study demonstrate that decreasing the insulin level in the primary hepatocyte culture medium enhanced xenobiotic mediated CYP2E1 expression, whereas lower insulin levels suppressed xenobiotic mediated CYP2B, CYP3A , and CYP4A expression in this cell culture system
Borbás et al., Eur J Pharm Sci 2006 (Diabetes Mellitus, Experimental) : These results indicate that insulin is involved in the regulation of hepatic FMO1 and intestinal CYP3A in rats
Hasegawa et al., J Pharm Pharmacol 2010 (Diabetes Mellitus, Experimental) : Effects of insulin on CYP3A activity and nicardipine disposition in streptozotocin induced diabetic rats