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G6PC2 — INS

Text-mined interactions from Literome

Sekar et al., Endocrinology 1999 : The basic differences between them are as follows : 1 ) vanadate promotes glycogenesis through the activation of a cytosolic protein tyrosine kinase, in an insulin-receptor independent manner ; 2 ) vanadate elevates glucose-6-phosphate ( G-6-P ) to a higher level than insulin ; 3 ) vanadate activated glycogenesis is accompanied by an increase in the cellular content of immunoreactive glycogen synthase, an effect less noticeable with insulin ; 4 ) adipose glucose-6-phosphatase is inhibited by vanadate ( dose for 50 % inhibition, IC50 = 7 +/- 0.7 microM ) but not by insulin
Lochhead et al., Diabetes 2000 : 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase
Lochhead et al., Diabetes 2001 (Diabetes Mellitus, Type 2...) : For example, the expression of two hepatic genes, glucose-6-phosphatase and PEPCK, is normally inhibited by insulin , but in type 2 diabetes, their expression is insensitive to insulin
Kino et al., Diabetes 2005 (Acquired Immunodeficiency Syndrome...) : Moreover, Vpr antagonized insulin induced suppression of the mRNA expression of the glucose 6-phosphatase , manganese superoxide dismutase, and sterol carrier protein 2 genes, which are known targets of insulin and FOXO, in HepG2 cells
Morioka et al., Int J Mol Med 2005 (Carcinoma, Hepatocellular) : Metformin induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells
Liang et al., Metabolism 2005 (Diabetes Mellitus, Experimental...) : The ASO-GCCR treated mice also showed significant enhancement of insulin mediated inhibition of hepatic glucose production during a euglycemic-hyperinsulinemic clamp as well as marked reduction of phosphoenolpyruvate carboxykinase and glucose 6-phosphatase activity compared with control mice
Andreelli et al., Endocrinology 2006 (Disease Models, Animal...) : This was confirmed in vivo by normal insulin induced phosphorylation of Akt and transcriptional regulation of the phosphoenolpyruvate carboxykinase, glucose-6 phosphatase , and pyruvate kinase in liver during the fasted/fed transition
Zhang et al., Biochem J 2006 : The inhibitory effect of resveratrol on insulin signalling is also demonstrated at mRNA level, where resveratrol reverses insulin effects on phosphoenolpyruvate carboxykinase, glucose-6-phosphatase , fatty acid synthase and glucokinase
Porterfield et al., Horm Metab Res 1979 : The effects of growth hormone, thyroxine and insulin on the activities of reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, glucose-6-phosphatase and glycogen phosphorylase in fetal rat liver
Muthulakshmi et al., Biochimie 2013 (Diabetes Mellitus, Experimental...) : Among the three doses, 80 mg/kg BW of AzA was able to positively regulate plasma glucose, insulin , blood HbA1c and haemoglobin levels by significantly increasing the activity of hexokinase and glucose-6-phosphate dehydrogenase and significantly decreasing the activity of glucose-6-phosphatase and fructose-1,6-bisphosphatase thereby increasing the glycogen content in the liver
Streeper et al., J Biol Chem 1997 : A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin
Dickens et al., J Biol Chem 1998 : Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin