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IGFBP6 — INS
Text-mined interactions from Literome
Hodgson et al., Regul Pept 2000
:
Insulin-like growth factor binding proteins (
IGFBP ) can
inhibit or accentuate the mitogenic activities of
insulin-like growth factor 1 (IGF-1) depending upon the experimental model employed
Dahlfors et al., Endocrinology 2000
:
IGF-I,
insulin , or angiotensin II did not
affect IGF-I or
IGFBP mRNA expression
Mesotten et al., J Clin Endocrinol Metab 2002
(Chronic Disease...) :
In the liver,
IGFBP-1 is transcriptionally
repressed by
insulin , and it is therefore a potential marker of hepatic insulin sensitivity
Hsu et al., J Biol Chem 1992
:
Unlike cell associated IGFBP-30K, secretion of IGFBP was stimulated ( 6.8 +/- 0.5-fold, n = 2 ) by IGF-I, whereas
IGFBP secretion was
inhibited 54 % by
insulin
Grimes et al., Endocrinology 1992
:
IGF-I, IGF-II, and the IGF-I analogs, but not
insulin , also
induced production of an unidentified 30-kDa
IGFBP not normally detectable in these cultures ... However, in the presence of epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ),
insulin also
induced this 30-kDa
IGFBP
Giudice et al., J Clin Endocrinol Metab 1992
:
Since insulin-like growth factors (IGFs) and IGF binding proteins ( IGFBPs ) are believed to be involved in endometrial differentiation, and
insulin regulates
IGFBP production in a variety of cells, we have investigated the modulatory roles of EGF, progesterone, and insulin on IGFBP secretion by long term cultures of human endometrial stromal cells ... In the nondecidualized state,
insulin increased the secretion of IGFBP-3,
IGFBP-2 , and the 24-kDa IGFBP, which were slightly inhibited by EGF and relatively unaffected by progesterone alone
Hwang et al., Growth Horm IGF Res 2003
(Carcinoma, Hepatocellular...) :
In normal physiology,
IGFBP-1 transcription is potently
inhibited by
insulin and serum levels are limited by a rapid clearance rate
Thraikill et al., J Clin Invest 1990
:
Cultured human decidual cells release three IGF-BPs with 24,000, 30,000, and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ), we examined the
effects of IGF-I ( 10-1,000 ng/ml ),
insulin ( 10-10,000 ng/ml ), and relaxin ( 10-250 ng/ml ) on decidual cell
IGF-BP release after 120 h of hormone exposure
Zhang et al., Biochem Biophys Res Commun 2007
(Diabetes Mellitus, Type 2) :
In contrast,
IGFBP-1 augmented glucose stimulated
insulin secretion in intact islets, associated with a reduced somatostatin secretion
Martin et al., Endocrinology 1990
(Cell Transformation, Neoplastic) :
Insulin tested at 1 microgram/ml did not
induce 29-31 K
IGFBP
Fang et al., Mol Biol Rep 2012
:
Insulin also
up-regulated the expression of GHR, IR,
IGFBP3 , and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA
Pekonen et al., Fertil Steril 1989
(Obesity...) :
The authors evaluated the
role of
insulin in the regulation of serum levels of 34K
IGF-BP in patients with polycystic ovarian disease ( PCOD )
Irwin et al., Regul Pept 1993
:
We have investigated the
regulation by
insulin , IGF-I, and IGF-II, of
IGFBP secretion in human endometrial stromal cells decidualized in vitro, and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs
McFarland et al., Gen Comp Endocrinol 1993
:
Equimolar levels of IGF-I or
insulin stimulated
IGFBP release, however, at levels lower than that induced by IGF-II
Lee et al., Proc Soc Exp Biol Med 1993
:
Furthermore,
IGFBP-1 regulation by
insulin and glucoregulatory hormones in vitro and limited in vivo data are consistent with a role for IGFBP-1 in glucose counterregulation
McCusker et al., J Cell Physiol 1998
:
IGFBP secretion by L6 cells is
stimulated by both
insulin/IGF-I and cAMP dependent pathways, whereas IGFBP-5 secretion by BC3H-1 cells is stimulated only by the insulin/IGF pathway