Gene interactions and pathways from curated databases and text-mining

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CDK2 — TAT

Text-mined interactions from Literome

Chun et al., Cancer Lett 2004 : PEP8-TAT2 , a membrane-permeable peptide, inhibits cyclin-Cdk2 activity in HeLa cells
Bhattacharya et al., J Infect 2009 (HIV Infections) : These agents include chemokine receptor antagonists and the integrase inhibitors which were recently approved for HIV treatment, as well as numerous other agents directed to previously untested targets such as the maturation inhibitors, zinc finger inhibitors, pharmacological CDK inhibitors, Tat-TAR interaction inhibitors , anti-CD4 monoclonal antibody, antisense oligonucleotides, oxidisers of the HIV lipid envelope and agents acting on the proviral DNA
Debebe et al., Mol Pharmacol 2011 : Tat itself is phosphorylated by CDK2, and inhibition of CDK2 by small interfering RNA, the iron chelator 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone ( 311 ), and the iron chelator deferasirox ( ICL670 ) inhibits HIV-1 transcription