Kaneki et al., J Biol Chem 2006
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We treated C2C12 and 2T3 osteoblast precursor cell lines and primary osteoblasts with TNF and found that TNF, but not interleukin-1 , significantly increased Smurf1 and Smurf2 expression
Verma et al., J Biol Chem 2012
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Increased expression of SMAD7 and SMURF2 in LFA-1/ICAM-1 cross linked T-cells resulted in impaired TGF-ß mediated phosphorylation of SMAD2 and suppression of IL-2 secretion