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BMP2 — MAP3K7
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
TAK1/SMAD6 complex (MAP3K7-SMAD6)
(modification, activates)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, activates)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Kimura et al., J Biol Chem 2000
:
We demonstrate that
BMP2 induces activation of TGF-beta activated kinase (
TAK1 ) and subsequent phosphorylation of p38 stress activated protein kinase ... Interestingly, this ectopic expression of Smad6 blocks
BMP2 induced
TAK1 activation and p38 phosphorylation
Qiao et al., J Biol Chem 2005
:
Transforming growth factor ( TGF ) -beta,
bone morphogenetic protein ( BMP ) , and interleukin-1beta
activate TGF-beta activated kinase 1 (TAK1) , which lies upstream of the p38 MAPK, JNK, and NF-kappaB pathways
Shim et al., EMBO J 2009
:
These findings provide the first in vivo evidence in a mammalian system that
TAK1 is
required for
BMP signalling and functions as an upstream activating kinase for Smad1/5/8 in addition to its known role in regulating MAP kinase pathways
Greenblatt et al., Ann N Y Acad Sci 2010
(Bone Diseases, Developmental) :
TAK1 mediates
BMP signaling in cartilage
Yumoto et al., J Biol Chem 2013
(Cleft Palate) :
Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells,
Tak1 is not only
required for TGF-ß- and
bone morphogenetic protein induced p38 Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads
Yamaguchi et al., Science 1995
:
Furthermore, kinase activity of
TAK1 was stimulated in
response to TGF-beta and
bone morphogenetic protein
Shibuya et al., EMBO J 1998
:
Role of
TAK1 and TAB1 in
BMP signaling in early Xenopus development