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IGF1 — PRKCG
Text-mined interactions from Literome
Lin et al., Invest Ophthalmol Vis Sci 2003
:
IGF-I stimulated activation and translocation of
PKCgamma in a dose- and time dependent manner, acidic FGF (aFGF) had no effect on translocation of PKCgamma, and PKCalpha was not translocated by IGF-I at 25 ng/mL ...
IGF-I- or DAG induced
activation of
PKCgamma caused a decrease in gap junctions ...
IGF-I caused an increase in DAG, and this increased translocation of
PKCgamma , whereas mobilization of calcium was not essential for IGF-I stimulated translocation of PKCgamma
Lin et al., Invest Ophthalmol Vis Sci 2003
:
Phorbol ester ( TPA ) and insulin-like growth factor
(IGF)-1 recruited PKCgamma into Cav-1 containing lipid rafts and
stimulated the interactions of
PKCgamma with Cav-1 and Cx43 ...
Activation of
PKCgamma by TPA or
IGF-1 stimulated the interaction of PKCgamma with Cav-1 and Cx43 in lipid rafts, causing Cx43, Cav-1, and PKCgamma to redistribute within the lipid rafts, and this resulted in a decrease in gap junction plaques
Nguyen et al., J Biol Chem 2004
:
We have shown previously that
insulin-like growth factor-I or lens epithelium derived growth factor
increases the translocation of
protein kinase Cgamma ( PKCgamma ) to the membrane and the phosphorylation of Cx43 by PKCgamma and causes a subsequent decrease of gap junction activity ( Nguyen, T. A., Boyle, D. L., Wagner, L. M., Shinohara, T., and Takemoto, D. J. ( 2003 ) Exp. Eye Res. 76, 565-572 ; Lin, D., Boyle, D. L., and Takemoto, D. J. ( 2003 ) Investig