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CASP8 — DAP3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TRAIL signaling pathway:
Caspase 8 (CASP8)
→
TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3)
(modification, collaborate)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Miyazaki et al., Nat Immunol 2001, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
Caspase 8 (CASP8)
→
TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3)
(modification, collaborate)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Tran et al., J Biol Chem 2001, Miyazaki et al., Nat Immunol 2001, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Miyazaki et al., Nat Immunol 2001
:
We have also found that binding of
DAP3 to FADD and
activation of
pro-caspase-8 in an in vitro reconstituted system is GTP dependent
Miyazaki et al., J Biol Chem 2004
(Neoplasm Metastasis) :
Conversely, overexpression of
DAP3 augmented cell death and
caspase activation induced by cell detachment ... Furthermore, the association of
DAP3 with FADD and the
activation of
caspase-8 were induced by cell detachment