Kanei-Ishii et al., Genes Dev 2004
(Leukemia, Myeloid) :
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
Kurahashi et al., Mol Biol Cell 2005
:
Recently we have shown that c-Myb is degraded in response to Wnt-1 stimulation via a pathway involving TAK1 ( TGF-beta activated kinase ), HIPK2 ( homeodomain interacting protein kinase 2 ), and NLK ( Nemo-like kinase )
Kanei-Ishii et al., J Biol Chem 2008
:
Treatment of M1 cells with Fbxw7 small interfering RNA ( siRNA ) rescued the Wnt induced c-Myb degradation and also the Wnt induced inhibition of cell proliferation