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CREB3 — IGF1
Text-mined interactions from Literome
Bruning et al., Proc Natl Acad Sci U S A 2000
:
Thus Rsk-2 is required for growth factor stimulated expression of c-Fos and transcriptional activation of Elk-1 and the serum response factor, but not for activation of
CREB or the mitogen activated protein kinase pathway in
response to PDGF and
IGF-1 stimulation
Grimes et al., J Neurochem 2001
:
Conversely, overexpression of active GSK3 beta to 3.5-fold the normal levels completely blocked increases in
CREB DNA binding activity
induced by epidermal growth factor,
insulin-like growth factor-1 , forskolin, and cyclic AMP
Mehrhof et al., Circulation 2001
:
IGF-I also
induced phosphorylation of cAMP response element binding protein (
CREB ) in a PI3K- and MEK1 dependent manner
Liu et al., Endocrinology 2002
:
IGF-I increased
CREB phosphorylation at a concentration as low as 10 ng/ml, and this effect was inhibited by H89, a PKA inhibitor, and PD98059, a MAPK kinase inhibitor ... Consistent with the effect of IGF-I on CREB phosphorylation,
IGF-I increased the transcriptional activity of
CREB , although it had no effect on CREB binding to DNA ... Consistent with the effect of IGF-I on CREB phosphorylation,
IGF-I increased the transcriptional activity of
CREB , although it had no effect on CREB binding to DNA
Zheng et al., J Biol Chem 2002
:
Gel mobility shift assay using a double stranded oligonucleotide for the CREB site in the promoter region, and competition experiments with excess unlabeled or mutated promoter oligonucleotide, and unlabeled consensus CREB oligonucleotide demonstrated that
IGF-1 induces
CREB binding to the DHPR alpha ( 1S ) promoter
Moorehead et al., Oncogene 2003
(Adenocarcinoma, Bronchiolo-Alveolar...) :
Moreover,
IGF-II induced proliferation and
CREB phosphorylation in human lung cancer cell lines, suggesting that IGF-II and CREB also contribute to the growth of human lung tumors
Zhong et al., J Neurosci Res 2004
:
We demonstrated also that high K ( + ) -induced depolarization, but not
IGF-1 ,
increased phosphorylation of cAMP-response element binding protein (
CREB ) and protein synthesis, both of which can be blocked by UO126
Zheng et al., J Membr Biol 2004
:
IGF-1 significantly
increased CaM kinase and calcineurin activity and the cellular levels of phosphorylated
CREB in a time dependent manner ... These results support the conclusion that
IGF-1 controls
CREB phosphorylation by activating a phosphorylation and dephosphorylation cascade, which ultimately modulates the DHPRalpha ( 1S ) gene transcription
Fernández et al., J Mol Endocrinol 2005
:
IGF-I and vasoactive intestinal peptide (VIP)
regulate cAMP-response element binding protein (
CREB ) -dependent transcription via the mitogen activated protein kinase ( MAPK ) pathway in pituitary cells : requirement of Rap1 ...
IGF-I induced cAMP-response element ( CRE ) -binding protein (
CREB ) phosphorylation through the Ras-MAPK pathway, whereas VIP phosphorylated CREB directly via PKA ... In summary, we showed that
IGF-I and VIP
stimulated MAPK activity and the phosphorylation of
CREB in pituitary cells
Maldonado et al., Biochem Biophys Res Commun 2005
(Calcium Signaling) :
Because in these cells IGF-1 induces intracellular Ca ( 2+ ) increase, we assessed whether the cyclic AMP response element binding protein (
CREB ) is
activated by
IGF-1 through Ca ( 2+ ) -dependent signalling pathways ... In cultured cardiac myocytes,
IGF-1 induced phosphorylation ( 6.5 +/- 1.0-fold at 5 min ), nuclear translocation ( 30 min post-stimulus ) and DNA binding activity of
CREB ... In cultured cardiac myocytes,
IGF-1 induced phosphorylation ( 6.5 +/- 1.0-fold at 5 min ), nuclear translocation ( 30 min post-stimulus ) and DNA binding activity of
CREB ...
IGF-1 induced
CREB phosphorylation was mediated by MEK1/ERK, PI3-K, p38-MAPK, as well as Ca ( 2+ ) /calmodulin kinase and calcineurin ... Exposure of cardiac myocytes to hyperosmotic stress ( sorbitol 600 mOsm ) decreased
IGF-1 induced
CREB activation Moreover, overexpression of a dominant negative CREB abolished the anti-apoptotic effects of IGF-1
Willaime-Morawek et al., Brain Res Mol Brain Res 2005
:
Analysis of the signal transduction pathways revealed that
IGF-I induces CREB phosphorylation via PI-3K and ERK, whereas simultaneous ceramide and IGF-I treatment decreases
CREB phosphorylation
Zheng et al., BMC neuroscience 2006
(MAP Kinase Signaling System) :
These data suggest that
IGF-1 induced the activation of Akt and
CREB using distinct pathways in PC12 cells
Singh et al., International journal of biological sciences 2007
:
IGF-1 increases the cyclic AMP-responsive element ( CRE ) binding transcription factor
CREB phosphorylation at Ser 133 and CRE binding activity in mesangial cells, which parallels cyclin D1 and fibronectin expressions
Ishida et al., Am J Physiol Endocrinol Metab 2007
:
Insulin-like growth factor I (IGF-I) , a potent mitogen in lactotrophs, did not affect intracellular cAMP concentrations but transiently
increased lactotroph
CREB phosphorylation
Genua et al., Cancer Res 2009
(Prostatic Neoplasms) :
In conclusion, we describe a novel mechanism of
IGF-IR up-regulation and promoter activity by
CREB activation, induced by sex steroids, through a nongenotropic signaling
Yan et al., Dev Neurobiol 2013
:
Consistently, Western immunoblot analysis demonstrated that IGF-I
induced CREB ( CRE binding protein ) phosphorylation, while ablation of CREB expression with small interfering RNAs ( siRNA ) blocked
IGF-I actions on cyclin D1 mRNA expression and cell proliferation ... Additionally,
IGF-I stimulated
CREB phosphorylation was blunted by the MAP kinase inhibitor, PD98059, but not by the PI3 kinase inhibitor, wortmannin ... Additionally,
IGF-I stimulated
CREB phosphorylation was blunted by the MAP kinase inhibitor, PD98059, but not by the PI3 kinase inhibitor, wortmannin ... ChIP assays revealed that
IGF-1 increased the association of
CREB with the cyclin D1 promoter
Pugazhenthi et al., J Biol Chem 1999
:
CREB phosphorylation at serine 133 and its transcriptional activation as measured by a CREB-specific Gal4-CREB reporter and the neuroendocrine-specific gene chromogranin A was
induced 2-3.3-fold by insulin-like growth factor
(IGF)-I ... Constitutively active and dominant negative regulators of the Ras and PI 3-kinase pathways confirmed the contribution of these pathways for
CREB regulation by
IGF-I