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LPA — RAC1

Text-mined interactions from Literome

He et al., Hypertension 2001 (Cardiovascular Diseases...) : The nonreceptor tyrosine kinase Src and the small GTPase Rac mediate the effects of both ET and LPA in stimulation of the hBNP promoter ... These data suggest that ( 1 ) ET activates the hBNP promoter through a transcriptional mechanism ; ( 2 ) LPA, perhaps generated by iPLA ( 2 ), is involved in the effect of ET ; ( 3 ) Src and Rac mediate ET and LPA stimulation of the hBNP promoter ; and ( 4 ) ET regulation of the hBNP promoter targets both distal and proximal cis elements
Stähle et al., J Cell Sci 2003 (Neoplasm Metastasis...) : Thus, pancreatic tumor cell migration in response to LPA is essentially controlled by activation of a Gi/o-ERK pathway and requires the LPA induced activation of Ras, Rac1 and RhoA
Mayeenuddin et al., J Biol Chem 2006 : LPA increased the amount of GTP bound Rac in the cells and isoproterenol reduced basal levels of GTP bound Rac and blunted the effect of LPA
Sugimoto et al., Exp Cell Res 2006 : Rho dependent, Rho kinase independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells ... Without PTX pretreatment, LPA stimulates Rac and cell migration yet similarly activates Rho, indicating that Rho activation by itself is not sufficient for inhibition of cell migration
Pilquil et al., J Biol Chem 2006 : These included decreased LPA induced activation of ERK and Rho, and the basal activities of Rac and Cdc42
Lee et al., Mol Biol Cell 2008 (Colonic Neoplasms...) : Consistent with negative modulation of the phosphatidylinositol 3 kinase pathway by LPA ( 4 ), LPA ( 4 ) deficiency potentiated Akt and Rac but decreased Rho activation induced by LPA
Harper et al., Cancer Res 2010 (Neoplasm Invasiveness...) : We further provide evidence that LPA ( 4 ) signaling in fibrosarcoma cells regulates invadopodia formation downstream of ATX, a process mediated through the activation of EPAC by cyclic AMP and subsequent Rac1 activation
Chen et al., Cancer Res 2010 (Neoplasm Metastasis...) : Instead, we find that LPA can activate Rac only in metastatic cells and that metastatic colonization of ovarian cancer cells necessitates Rac activity ... These results thus suggest that LPA induced Rac activation is a prerequisite for ovarian cancer metastasis
O'Connor et al., Am J Physiol Cell Physiol 2012 : We also determine that integrin a ( 6 ) ß ( 4 ) can not activate Rac1 directly but promotes LPA mediated Rac1 activation that is dependent on RhoA activity and de novo ß ( 1 ) integrin ligation ... Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA, and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization
Stam et al., EMBO J 1998 (Lymphoma, T-Cell...) : Our results indicate that T-lymphoma invasion is driven by Tiam1/Rac or Cdc42 activation, and is dependent on LPA/S1P receptor mediated RhoA and PLC signaling pathways which lead to pseudopod formation and enhanced infiltration