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Klouche et al., Arterioscler Thromb Vasc Biol 1999
(Arteriosclerosis) :
In endothelial cells,
E-LDL stimulated upregulation of intercellular adhesion molecule-1 ( ICAM-1 ), platelet-endothelial cells adhesion molecule-1 ( PECAM-1 ), P-selectin, and
E-selectin with distinct kinetics
Cominacini et al., Cell adhesion and communication 1999
:
Oxidized
LDL not only
caused a dose dependent increase of ICAM-1, VCAM-1 and
E-selectin ( p < 0.001 ), but also synergically increased their TNF-alpha induced expression ( p < 0.001 )
Colomé et al., Atherosclerosis 2000
(Arteriosclerosis) :
LDL did not
induce the expression of the intercellular cell adhesion molecule-1 ( ICAM-1 ), vascular cell adhesion molecule-1 ( VCAM-1 ) or
E-selectin , but it produced a downregulation of endothelial nitric oxide synthase ( NOS III ) mRNA levels
Zhu et al., Arterioscler Thromb Vasc Biol 2001
:
To study the effect of p38 in the regulation of an LDL targeting gene, we show that a specific p38 inhibitor attenuates
LDL induced
E-selectin at the mRNA level
Cominacini et al., Am J Hypertens 2002
:
Although zofenoprilat significantly and dose dependently reduced the expression of vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular cell adhesion molecule-1 ( ICAM-1 ), and
E-selectin induced by
ox-LDL ( P < .01 ) and TNF-alpha ( P < .01 ) on HUVECs, enalaprilat did not
Zhu et al., Frontiers in bioscience : a journal and virtual library 2005
:
Ox-LDL increased the expression of ICAM-1 and
E-selectin in a concentration ( 10-50 microg/ml ) -- and time ( 6-36 hours ) -- dependent manners ... Preincubating HUVECs with 15d-PGJ2 attenuated the expression of ICAM-1 and
E-selectin in
response to
ox-LDL , although ox-LDL stimulated the expression of PPARgamma ... Upregulation of ICAM-1 and
E-selectin mediated by
ox-LDL were inhibited more significantly by the combination of 15d-PGJ2 and polyinosonic acid as compared to either 15d-PGJ2 or polyinosonic acid alone
Zhu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2005
:
The expression of LOX-1, ICAM-1 and
E-selectin induced by
ox-LDL were reduced in HUVECs pretreated with 250 microg/ml poly ( I ) or 250 microg/ml carrageenan for 2 h and then incubated with 50 microg/ml ox-LDL for 24 h ... This showed that both poly ( I ) and carrageenan obviously decreased the expression of LOX-1, ICAM-1 and
E-selectin induced by
ox-LDL
Lei et al., J Nutr 2008
:
Diallyl disulfide and diallyl trisulfide suppress oxidized
LDL induced vascular cell adhesion molecule and
E-selectin expression through protein kinase A- and B-dependent signaling pathways ... In contrast, wortmannin abolished DADS- and DATS induced suppression of
ox-LDL induced
E-selectin expression ... These results suggest that the suppression of
ox-LDL induced
E-selectin and VCAM-1 expression by DADS and DATS and, thus, monocyte adhesion to endothelial cells is likely dependent on the PI3K/PKB or PKA/CREB signaling pathway in an adhesion molecule-specific manner
Lii et al., J Ethnopharmacol 2010
:
reduces the oxidized
LDL induced expression of intercellular adhesion molecule-1 and
E-selectin in human umbilical vein endothelial cells
Cominacini et al., J Hypertens 1997
:
The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1, VCAM-1 and
E-selectin induced by TNF-alpha alone or with oxidized
LDL ( P < 0.001 )